Results 41 to 50 of about 145,423 (282)

Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins

Viruses, 2018
Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain ...
Evgeny N. Kozlov, Elena U. Martynova, Vladimir I. Popenko, Coby Schal, Dmitry V. Mukha   +4 more
doaj   +1 more source

Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly

Communications Biology, 2022
A 2.9 Å resolution structure of the L-BC virus provides insight into the contacts between capsid proteins and the mechanism of capsid assembly.
Danyil Grybchuk, Michaela Procházková, Tibor Füzik, Aleksandras Konovalovas, Saulius Serva, Vyacheslav Yurchenko, Pavel Plevka   +6 more
doaj   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Production of FMDV virus-like particles by a SUMO fusion protein approach in Escherichia coli

Journal of Biomedical Science, 2009
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications as carriers for foreign antigens or as ...
Liang Shu-Mei, Yan Yao-Pei, Lee Chien-Der, Wang Ting-Fang   +3 more
doaj   +1 more source

Modest truncation of the major capsid protein abrogates B19 parvovirus capsid formation [PDF]

Journal of Virology, 1995
In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structure by expressing progressively more
M, Kawase, M, Momoeda, N S, Young, S, Kajigaya   +3 more
openaire   +2 more sources

Intrinsically-disordered N-termini in human parechovirus 1 capsid proteins bind encapsidated RNA

Scientific Reports, 2018
Human parechoviruses (HPeV) are picornaviruses with a highly-ordered RNA genome contained within icosahedrally-symmetric capsids. Ordered RNA structures have recently been shown to interact with capsid proteins VP1 and VP3 and facilitate virus assembly ...
Shabih Shakeel, James D. Evans, Mark Hazelbaker, C. Cheng Kao, Robert C. Vaughan, Sarah J. Butcher   +5 more
doaj   +1 more source

Control of Capsid Transformations during Reovirus Entry

Viruses, 2021
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate.
Stephanie L. Gummersheimer, Anthony J. Snyder, Pranav Danthi   +2 more
doaj   +1 more source

The papillomavirus major capsid protein L1

Virology, 2013
The elegant icosahedral surface of the papillomavirus virion is formed by a single protein called L1. Recombinant L1 proteins can spontaneously self-assemble into a highly immunogenic structure that closely mimics the natural surface of native papillomavirus virions. This has served as the basis for two highly successful vaccines against cancer-causing
Buck, Christopher B., Day, Patricia M., Trus, Benes L.   +2 more
openaire   +2 more sources

The role of post-translational modifications in parvovirus life cycle

Frontiers in Veterinary Science
Parvoviruses are a group of single-stranded DNA viruses that lack an envelope and are widely distributed in both vertebrates and invertebrates. When they infect a host cell, parvoviruses take over the cell’s translational machinery to support the viral ...
Peng Liu, Liqin Yang
doaj   +1 more source

Capsid protein structure in Zika virus reveals the flavivirus assembly process

Nature Communications, 2020
The structure of flavivirus surface proteins has been elucidated, but the conformation of capsid proteins within particles is less clear. Here, the authors provide a subnanometer resolution structure of Zika virus capsid protein within the virus particle,
Ter Yong Tan, Guntur Fibriansah, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Xiang Lim, Shuijun Zhang, Xin-Ni Lim, Jiaqi Wang, Jian Shi, Marc C. Morais, Davide Corti, Shee-Mei Lok   +11 more
doaj   +1 more source