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Control of Capsid Transformations during Reovirus Entry
Viruses, 2021 Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate.
Stephanie L. Gummersheimer +2 more
doaj +1 more source
L2, the minor capsid protein of papillomavirus
Virology, 2013 The capsid protein L2 plays major roles in both papillomavirus assembly and the infectious process. While L1 forms the majority of the capsid and can self-assemble into empty virus-like particles (VLPs), L2 is a minor capsid component and lacks the capacity to form VLPs. However, L2 co-assembles with L1 into VLPs, enhancing their assembly.
Richard B.S. Roden, Joshua W. Wang
openaire +3 more sources
Assembly and Translocation of Papillomavirus Capsid Proteins [PDF]
Journal of Virology, 2002 ABSTRACT The major and minor capsid proteins of polyomavirus are preassembled in the cytoplasm and translocated to the nucleus only as a VP1-VP2/VP3 complex. In this study, we describe independent nuclear translocation of the L1 major protein and the L2 minor capsid protein of human papillomavirus type 33 by several approaches.
Rolf E. Streeck +3 more
openaire +3 more sources
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Intrinsically-disordered N-termini in human parechovirus 1 capsid proteins bind encapsidated RNA
Scientific Reports, 2018 Human parechoviruses (HPeV) are picornaviruses with a highly-ordered RNA genome contained within icosahedrally-symmetric capsids. Ordered RNA structures have recently been shown to interact with capsid proteins VP1 and VP3 and facilitate virus assembly ...
Shabih Shakeel +5 more
doaj +1 more source
Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins
Viruses, 2018 Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain ...
Evgeny N. Kozlov +4 more
doaj +1 more source
Biology Direct, 2014 Polintons (also known as Mavericks) and Tlr elements of Tetrahymena thermophila represent two families of large DNA transposons widespread in eukaryotes.
M. Krupovic, D. Bamford, E. Koonin
semanticscholar +1 more source
ACS Synthetic Biology, 2013 M13 bacteriophage has been used as a scaffold to organize materials for various applications. Building more complex multiphage devices requires precise control of interactions between the M13 capsid proteins.
Gaelen T. Hess +4 more
semanticscholar +1 more source
bioRxiv, 2020 HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization and mechanism of uncoating are under debate. We adapted a strategy to visualize individual reverse-transcribed HIV-1 cDNA molecules and their association with viral
Thorsten G. Müller +9 more
semanticscholar +1 more source
Statistical analysis of sizes and shapes of virus capsids and their resulting elastic properties [PDF]
J. Biol. Phys. 39, 215-228 (2013), 2012 From the analysis of sizes of approximately 130 small icosahedral viruses we find that there is a typical structural capsid protein, having a mean diameter of 5 nm and a mean thickness of 3 nm, with more than two thirds of the analyzed capsid proteins having thicknesses between 2 nm and 4 nm.
arxiv +1 more source