Results 51 to 60 of about 6,660,257 (317)
Self-assembly of model proteins into virus capsids
, 2017 We consider self-assembly of proteins into a virus capsid by the methods of molecular dynamics. The capsid corresponds either to SPMV or CCMV and is studied with and without the RNA molecule inside.
Cieplak, Marek, Wolek, Karol
core +1 more source
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +3 more sources
The papillomavirus major capsid protein L1
Virology, 2013 The elegant icosahedral surface of the papillomavirus virion is formed by a single protein called L1. Recombinant L1 proteins can spontaneously self-assemble into a highly immunogenic structure that closely mimics the natural surface of native papillomavirus virions. This has served as the basis for two highly successful vaccines against cancer-causing
Buck, Christopher B. +2 more
openaire +2 more sources
The role of packaging sites in efficient and specific virus assembly
, 2015 During the lifecycle of many single-stranded RNA viruses, including many human pathogens, a protein shell called the capsid spontaneously assembles around the viral genome. Understanding the mechanisms by which capsid proteins selectively assemble around
Hagan, M. F., Perlmutter, J. D.
core +1 more source
Structure, Function, and Interactions of the HIV-1 Capsid Protein
Life, 2021 The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors.
Eric Rossi +3 more
semanticscholar +1 more source
The role of post-translational modifications in parvovirus life cycle
Frontiers in Veterinary ScienceParvoviruses are a group of single-stranded DNA viruses that lack an envelope and are widely distributed in both vertebrates and invertebrates. When they infect a host cell, parvoviruses take over the cell’s translational machinery to support the viral ...
Peng Liu, Liqin Yang
doaj +1 more source
Electrostatic theory of viral self-assembly: a toy model
, 2007 Viruses self-assemble from identical capsid proteins and their genome consisting, for example, of a long single stranded (ss) RNA. For a big class of T = 3 viruses capsid proteins have long positive N-terminal tails.
Adolph +17 more
core +1 more source
Molecular Studies on Bromovirus Capsid Protein
Virology, 1997 Specific interactions are likely to occur between the highly conserved N-proximal arginine-rich motif (ARM) of Brome mosaic virus (BMV) coat protein (CP) and each of three genomic RNAs and a single subgenomic RNA during in vivo encapsidation. To characterize these interactions, three independent deletions were engineered into a biologically active ...
Osman, Fatima +2 more
openaire +2 more sources
Radial distribution of RNA genome packaged inside spherical viruses
, 2008 The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid ...
J. Johnson +3 more
core +1 more source
Biology Direct, 2014 Polintons (also known as Mavericks) and Tlr elements of Tetrahymena thermophila represent two families of large DNA transposons widespread in eukaryotes.
M. Krupovic, D. Bamford, E. Koonin
semanticscholar +1 more source