Results 61 to 70 of about 6,660,257 (317)

Adeno-associated virus capsid assembly is divergent and stochastic

Nature Communications, 2020
Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped T = 1 icosahedral capsid of ~3.8 megaDalton, consisting of 60 subunits of 3 distinct viral proteins (VPs), which vary only in ...
Tobias P. Wörner, A. Bennett, Sana Habka, J. Snijder, O. Friese, Thomas W. Powers, M. Agbandje-McKenna, A. Heck   +7 more
semanticscholar   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Chiral Quasicrystalline Order and Dodecahedral Geometry in Exceptional Families of Viruses

, 2012
On the example of exceptional families of viruses we i) show the existence of a completely new type of matter organization in nanoparticles, in which the regions with a chiral pentagonal quasicrystalline order of protein positions are arranged in a ...
C. Janot, D. L. Caspar, L. D. Landau, M. Senechal, O. V. Konevtsova, P. G. de Gennes, P. J. Steinhardt, R. Penrose, S. B. Rochal, T. S. Baker, V. L. Lorman   +10 more
core   +5 more sources

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Molecular Studies on Bromovirus Capsid Protein

Virology, 1998
Brome mosaic bromovirus (BMV) and cucumber mosaic cucumovirus (CMV) are structurally and genetically very similar. The specificity of the BMV and CMV coat proteins (CPs) during in vivo encapsidation was studied using two RNA3 chimera in which the respective CP genes were exchanged.
Osman, Fatima, Choi, Yoon Gi, Grantham, George L., Rao, A.L.N.   +3 more
openaire   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

eLife, 2016
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly
Yen-Li Li, Viswanathan Chandrasekaran, Stephen D Carter, Cora L Woodward, Devin E Christensen, Kelly A Dryden, Owen Pornillos, Mark Yeager, Barbie K Ganser-Pornillos, Grant J Jensen, Wesley I Sundquist   +10 more
doaj   +1 more source

Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]

PLoS ONE, 2013
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang, Ju-Tao Guo, Jim Z Wu, Guang Yang   +3 more
doaj   +1 more source

Density waves theory of the capsid structure of small icosahedral viruses

, 2006
We apply Landau theory of crystallization to explain and to classify the capsid structures of small viruses with spherical topology and icosahedral symmetry.
D. L. D. Caspar, J. B. Bancroft, J. P. Elliot, L. D. Landau, L. D. Landau, S. B. Rochal, S. J. Flint, T. S. Baker, V. L. Lorman   +8 more
core   +3 more sources

The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell [PDF]

, 2012
The malaria parasite exports proteins across its plasma membrane and a surrounding parasitophorous vacuole membrane, into its host erythrocyte. Most exported proteins contain a Host Targeting motif (HT motif) that targets them for export. In the parasite
Cryar, Adam, Haldar, K., Osborne, Andrew R., Tarr, Sarah J., Thalassinos, Konstantinos   +4 more
core   +1 more source