Results 61 to 70 of about 5,586,089 (360)
Development of adenovirus capsid proteins for targeted therapeutic delivery.
Therapeutic delivery, 2013 The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. These stages include initial cell-surface binding
L. Medina-Kauwe
semanticscholar +1 more source
Structural transitions and energy landscape for Cowpea Chlorotic Mottle Virus capsid mechanics from nanomanipulation in vitro and in silico [PDF]
Biophys. J. 2013 Oct 15;105(8):1893-1903, 2015 Physical properties of capsids of plant and animal viruses are important factors in capsid self-assembly, survival of viruses in the extracellular environment, and their cell infectivity. Virus shells can have applications as nanocontainers and delivery vehicles in biotechnology and medicine.
arxiv +1 more source
Density waves theory of the capsid structure of small icosahedral viruses [PDF]
, 2006 We apply Landau theory of crystallization to explain and to classify the capsid structures of small viruses with spherical topology and icosahedral symmetry. We develop an explicit method which predicts the positions of centers of mass for the proteins constituting viral capsid shell.
arxiv +1 more source
Mechanisms of Size Control and Polymorphism in Viral Capsid Assembly [PDF]
Elrad, OM and Hagan MF: Nano Letters 8 : 3850 2008, 2008 We simulate the assembly dynamics of icosahedral capsids from subunits that interconvert between different conformations (or quasi-equivalent states). The simulations identify mechanisms by which subunits form empty capsids with only one morphology but adaptively assemble into different icosahedral morphologies around nanoparticle cargoes with varying ...
arxiv +1 more source
Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids
eLife, 2016 TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly
Yen-Li Li +10 more
doaj +1 more source
Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]
PLoS ONE, 2013 Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang +3 more
doaj +1 more source
Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
Science, 2019 The fitness landscape of AAV Adeno-associated virus (AAV) is an important gene therapy vector. Using tools from synthetic biology, Ogden et al. provide a comprehensive view of how sequence changes in capsid proteins affect AAV properties.
Pierce J. Ogden +3 more
semanticscholar +1 more source
Viral genome structures are optimal for capsid assembly [PDF]
eLife 2013;2:e00632, 2013 Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications. We develop a coarse-grained model of capsid proteins and NAs with which we investigate assembly dynamics and thermodynamics. In contrast to recent theoretical models, we
arxiv +1 more source
Modern Pathology, 2012 While cervical cancer screening relies on cervical cytology and high-risk human papillomavirus (HPV) detection, the histologic diagnosis, and specifically lesion grade, is the main parameter that drives clinical management of screen-positive women ...
A. Yemelyanova +6 more
semanticscholar +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source