NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken [PDF]
, 2001 Non-mammalian NK cells have not been characterized in detail; however, their analysis is essential for the understanding of the NK cell receptor phylogeny.
Manfred Stangassinger +5 more
core +1 more source
CAR‐NK cells: the next wave of cellular therapy for cancer [PDF]
Clinical & Translational Immunology, 2021 AbstractT cells engineered to express chimeric antigen receptors (CARs) have revolutionised the field of cellular therapy for cancer. Despite its success, this strategy has some recognised limitations and toxicities. Hence, there is growing interest in developing novel cellular therapies based on non‐αβ T‐cell immune effector cells, including NK cells ...
May Daher +3 more
openaire +3 more sources
Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy [PDF]
Cell Stem Cell, 2018 CAR-T therapy has shown great success treating blood cancers, but drawbacks include high manufacturing costs and potentially fatal toxicities such as cytokine release syndrome. In this issue of Cell Stem Cell, Li et al. (2018) describe how engineered iPSC-derived NK cells armed with NK-tailored CAR constructs (CAR-iPSC-NK cells) provide better options ...
Elizabeth L, Siegler +3 more
openaire +2 more sources
CAR-NK cells for cancer immunotherapy: from bench to bedside
Biomarker Research, 2022 Abstract Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of prior sensitization or recognition of peptide antigens.
Leisheng Zhang +3 more
openaire +3 more sources
A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG. [PDF]
, 2011 Subsets of NK cells can have distinct functions. Here, we report that >25% of human peripheral blood NK cells express HLA-DR after culture with IL-2.
Emma L. Wise +18 more
core +1 more source
Overcoming tumor resistance mechanisms in CAR-NK cell therapy
Frontiers in Immunology, 2022 Despite the impressive results of autologous CAR-T cell therapy in refractory B lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost-effective approach with no signs of severe toxicities as described for CAR-T cells.
Antonio Valeri +16 more
openaire +4 more sources
Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans
, 2022 The abundance of sialic acid-containing glycans in the glycocalyx of malignant cells enables immune evasion. Here, we leverage the biosynthetic pathways that permit pervasive sialylation to incorporate a chimeric antigen receptor (CAR) ligand into ...
Patrick A. Ross (12709860) +2 more
core +1 more source
The major advantages and early clinical obstacles of CAR-NK compared to CAR-T cell therapy
, 2023 Chimeric Antigen Receptor T-Cells (CAR-T) are genetically engineered T cells designed to recognize and attack specific cancer cells, thereby offering a targeted approach to cancer immunotherapy. Chimeric Antigen Receptor Natural Killer (CAR-NK) cells are
Chenyang Li
core +1 more source
NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness [PDF]
, 2021 Background Chimeric antigen receptor (CAR)-T cell immunotherapy has modified the concept of treatment in hematological malignancies. In comparison with pediatric patients, where responses are maintained over many years, older patients, such as those with
Najjar, Amer M. +22 more
core +1 more source
Preclinical and clinical studies of CAR-NK-cell therapies for malignancies
Frontiers in Immunology, 2022 The development of chimeric antigen receptor T (CAR-T) cell therapy, a specific type of immunotherapy, in recent decades was a fantastic breakthrough for the treatment of hematological malignancies. However, difficulties in collecting normal T cells from patients and the time cost of manufacturing CAR-T cells have limited the application of CAR-T-cell ...
Hongwen Li +12 more
openaire +3 more sources