Results 31 to 40 of about 80,532 (301)

Targeting T-cell malignancies using anti-CD4 CAR NK-92 cells [PDF]

Oncotarget, 2017
Peripheral T-cell lymphomas (PTCLs) are a group of very aggressive non-Hodgkin's lymphomas (NHLs) with poor prognoses and account for a majority of T-cell malignancies. Overall, the standard of care for patients with T-cell malignancies is poorly established, and there is an urgent clinical need for a new approach.
Pinz, Kevin G., Yakaboski, Elizabeth, Jares, Alexander, Liu, Hua, Firor, Amelia E., Chen, Kevin H., Wada, Masayuki, Salman, Huda, Tse, William, Hagag, Nabil, Lan, Fengshuo, Leung, Elaine Lai-Han, Jiang, Xun, Ma, Yupo   +13 more
openaire   +2 more sources

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

Frontiers in Immunology, 2023
Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however, their effectiveness against solid tumors remains a hurdle. Recently, CD44v6-directed CAR-T cells
Ioana Sonya Ciulean, Joe Fischer, Andrea Quaiser, Christoph Bach, Hinrich Abken, Uta Sandy Tretbar, Stephan Fricke, Ulrike Koehl, Ulrike Koehl, Dominik Schmiedel, Dominik Schmiedel, Thomas Grunwald   +11 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types [PDF]

, 2017
Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor ...
Aftimos, Philippe, Awada, Ahmad, Brayer, Jason B, Catala, Gaetan, Davila, Marco L, Gilham, David E, Hendlisz, Alain, Kerre, Tessa, Lehmann, Frederic F, Lonez, Caroline, Machiels, Jean-Pascal H, Odunsi, Kunle, Piette, Fanny, Sallman, David A, Van den Neste, Eric, Verma, Bikash   +15 more
core   +1 more source

Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]

, 2014
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W., Benkö M., Cauthen A.N., Crawford-Miksza L., Estrella Lopez-Gordo, Gall J., Gall J.G., Gattoni A., Ginsberg H.S., Haviv Y.S., Hofmann C., Iva I. Podgorski, Kajon A.E., Kanerva A., Kass-Eisler A., Kuriyama S., Mastrangeli A., Michou A.I., Nicholas Downes, Ramon Alemany, Rogozhin V.N., Roy S., Seiradake E., Shmarov M.M., Soudais C., Tutykhina I.L., Wang D.Y., Wohlfart C., Ying B., Zakhartchouk A.N., Zeng Q.   +30 more
core   +3 more sources

A fully-discrete-state kinetic theory approach to modeling vehicular traffic [PDF]

, 2012
This paper presents a new mathematical model of vehicular traffic, based on the methods of the generalized kinetic theory, in which the space of microscopic states (position and velocity) of the vehicles is genuinely discrete.
Fermo, Luisa, Tosin, Andrea
core   +2 more sources

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma

Journal of Immunology Research, 2017
The chimeric antigen receptor-modified immune effector cell (CAR-T and CAR-NK) therapies are newly developed adoptive treatments of cancers. However, their therapeutic efficacy against solid tumors is limited.
Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng   +8 more
doaj   +1 more source

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

iScience, 2021
Summary: Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against hematologic malignancies, severe off-tumor effects have constrained their use against solid tumors. Recently, CAR-engineered natural killer (NK) cells have emerged
Ana L. Portillo, Richard Hogg, Sophie M. Poznanski, Eduardo A. Rojas, Niamh J. Cashell, Joanne A. Hammill, Marianne V. Chew, Mira M. Shenouda, Tyrah M. Ritchie, Quynh T. Cao, Jeremy A. Hirota, Sukhbinder Dhesy-Thind, Jonathan L. Bramson, Ali A. Ashkar   +13 more
doaj   +1 more source

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +2 more sources