Results 41 to 50 of about 80,532 (301)
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Journal of Hematology & Oncology, 2020 Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding antigens, creating major opportunities in the fight against cancer.
Ahmet Yilmaz +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Cancer immunotherapies utilize the capabilities of the immune system to efficiently target malignant cells. In recent years, chimeric antigen receptor (CAR) equipped T cells showed promising results against B cell lymphomas.
Katharina Eva Ruppel +5 more
doaj +1 more source
Highly Efficient Generation of Transgenically Augmented CAR NK Cells Overexpressing CXCR4 [PDF]
Frontiers in Immunology, 2020 Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy. NK cells initiate innate immune responses against infections and malignancies with natural cytotoxicity, which is independent of foreign antigen recognition.
Arezoo Jamali +15 more
openaire +6 more sources
CAR-NK cells for cancer immunotherapy: from bench to bedside
Biomarker Research, 2022 AbstractNatural killer (NK) cells are unique innate immune cells and manifest rapid and potent cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of prior sensitization or recognition of peptide antigens. Distinguish from the T lymphocyte-based cythotherapy with toxic side effects, chimeric antigen receptor-transduced NK
Leisheng Zhang +3 more
openaire +3 more sources
Biological therapy in the treatment of melanoma [PDF]
, 2018 Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable ...
Benea, Vasile +8 more
core +3 more sources
Natural Killer cells responsiveness to physical esercise: a brief review [PDF]
, 2013 Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A. +4 more
core +1 more source
Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. [PDF]
, 1989 Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural and muscle tissues that is involved in homotypic adhesive interactions.
Bindl, J +3 more
core +1 more source
Immunotherapy of B cell lymphoma with CD22-redirected CAR NK-92 cells
Central European Journal of Immunology, 2023 Chimeric antigen receptor (CAR)-NK cells are considered safer than CAR-T cells due to their short lifetime and production of lower toxicity cytokines. By virtue of unlimited proliferative ability in vitro, NK-92 cells could be utilized as the source for CAR-engineered NK cells. CD22 is highly expressed in B cell lymphoma.
Xiaopeng Tian +7 more
openaire +3 more sources
Frontiers in Immunology, 2022 The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also highly ...
Maren Soldierer +19 more
doaj +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source