Results 41 to 50 of about 5,478,695 (241)
Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Irene Tirado-González +58 more
core +2 more sources
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Molecular Cancer, 2023 AbstractChimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer. However, the efficacy of CAR NK/T cell therapy is often hindered by various factors, including the phenomenon of trogocytosis, which involves the bidirectional exchange of membrane fragments between cells. In this review,
Faezeh Ramezani +6 more
openaire +3 more sources
Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk
, 2012 Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R +4 more
core +1 more source
Activation of natural killer cells during microbial infections. [PDF]
, 2011 Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M +8 more
core +1 more source
Design of NKG2D-based CAR-NK Cells Targeting Solid Tumors [PDF]
, 2023 Chimeric Antigen Receptor (CAR) engineered NK cells have been shown to enhance the activities of NK cells against cancer in both preclinical and clinical studies.
Wu, Lujing
core
Increased Activity of a NK-Specific CAR-NK Framework Targeting CD3 and CD5 for T-Cell Leukemias
, 2022 NK effector cells expressing a CAR construct may be used to target T-lineage markers. In this work, we compared the activity of a NK-specific CAR-NK and a CAR-T framework when expressed on NK effector cells to target CD3 and CD5 in T-cell malignancies ...
William G. Telford +6 more
core +1 more source
CAR NK cells for cancer retargeting
, 2018 Adaptive immunotherapy using redirected chimeric antigen receptor (CAR) T cells against leukemia has led to promising results with improved patient survival. The continuously increasing interest in those advanced gene therapy medicinal products leads to a manufacturing challenge regarding automation, process robustness, and cell storage.
Esser, Ruth +13 more
openaire +1 more source
Frontiers in Immunology, 2022 The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also highly ...
Maren Soldierer +19 more
doaj +1 more source
Generation of anti-CD19 CAR-NK cells as an allogeneic alternative for B-cell neoplasia treatment
, 2022 Recentemente, a terapia de neoplasias hematológicas foi revolucionada pelo uso de células T autólogas que expressam receptores quiméricos de antígenos (CAR).
Silvestre, Renata Nacasaki
core +1 more source
Prospect Of CAR-NK Cell In Tumor Immunotherapy
Highlights in Science, Engineering and Technology, 2023 The innate immune system has gained significant interest expected to the impressive natural killer (NK) cells ability to surveil and combat pathogens, regardless of major histocompatibility complex. Following the resounding success of CAR-T cell therapy, there has been a burgeoning interest in harnessing the NK therapeutics potential in recent years ...
openaire +1 more source