Results 51 to 60 of about 80,532 (301)

CAR NK cells for cancer retargeting

, 2018
Adaptive immunotherapy using redirected chimeric antigen receptor (CAR) T cells against leukemia has led to promising results with improved patient survival. The continuously increasing interest in those advanced gene therapy medicinal products leads to a manufacturing challenge regarding automation, process robustness, and cell storage.
Esser, Ruth, Koehl, Ulrike, Glienke, Wolfgang, Morgan, Michael, Kaiser, Andrew, Abken, Hinrich, Heuser, Michael, Aleksandrova, Krasimira, Leise, Jana, Oberschmidt, Olaf, Priesner, Christoph, Arseniev, Lubomir, Schambach, Axel, Kloess, Stephan   +13 more
openaire   +1 more source

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Frontiers in Immunology
Allogeneic natural killer (NK) cell therapy has demonstrated significant potential in cancer immunotherapy by harnessing NK cells to target malignancies.
Dong-Hyeon Jo, Dong-Hyeon Jo, Shelby Kaczmarek, Shelby Kaczmarek, Abrar Ul Haq Khan, Abrar Ul Haq Khan, Jannat Pervin, Jannat Pervin, Diana M. Clark, Suresh Gadde, Suresh Gadde, Suresh Gadde, Lisheng Wang, Lisheng Wang, Lisheng Wang, Scott McComb, Scott McComb, Scott McComb, Scott McComb, Alissa Visram, Alissa Visram, Alissa Visram, Seung-Hwan Lee, Seung-Hwan Lee, Seung-Hwan Lee   +24 more
doaj   +1 more source

Efficacy of Targeting SARS-CoV-2 by CAR-NK Cells [PDF]

, 2020
ABSTRACTSARS-CoV-2, which causes COVID-19 disease, is one of greatest global pandemics in history. No effective treatment is currently available for severe COVID-19 disease. One strategy for implementing cell-based immunity involves the use of chimeric antigen receptor (CAR) technology.
Minh Ma, Saiaditya Badeti, Ke Geng, Dongfang Liu   +3 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways

Experimental Hematology & Oncology
Background NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used to treat patients with relapsed and/or refractory B cell malignances, demonstrating encouraging outcomes and favorable ...
Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu   +14 more
doaj   +1 more source

CD33KO-CD33-mesothelin Loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia

Journal for ImmunoTherapy of Cancer
Background Patients with acute myeloid leukemia (AML) are often older, which brings challenges of endurance and persistent efficacy of autologous chimeric antigen receptor (CAR)-T cell therapies. Allogenic CAR-natural killer (NK) cell therapies may offer
Qi Chen, Qi Zhang, Xin Du, Xiaofan Zhu, Yao Wang, Yi Chen, Fan Zhang, Fangxiao Hu, Dehao Huang, Qitong Weng, Jinyong Wang, Lijuan Liu, Aibin Liang, Jiaxin Wu, Yanhong Liu, Pengcheng Liu, Wenbin Qian, Xiujuan Zheng, Zhiqian Wang, Ziyun Xiao, Yunqing Lin, Leqiang Zhang, Chengxiang Xia, Yanping Zhu, Hanmeng Qi, Yiyuan Shen, Chenyuan Zhang, Jiacheng Xu, Yaoqin Zhao, Tongjie Wang, Mengyun Zhang, Minming Li, Wenyu Yang, Tianyuan Hu   +33 more
doaj   +1 more source

Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Experimental Hematology & Oncology, 2022
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent achievement in the clinical immunotherapy of hematological malignant tumors, leading to a rapid development of cellular immunotherapy in cancer treatment.
Xiao Wang, Xuejiao Yang, Xiang Yuan, Wenbo Wang, Yueying Wang   +4 more
doaj   +1 more source

CAR-NK cell therapy: a potential antiviral platform

Science Bulletin
Viral infections persist as a significant cause of morbidity and mortality worldwide. Conventional therapeutic approaches often fall short in fully eliminating viral infections, primarily due to the emergence of drug resistance. Natural killer (NK) cells, one of the important members of the innate immune system, possess potent immunosurveillance and ...
Ming-Hao, Lin, Li-Juan, Hu, Jeffrey S, Miller, Xiao-Jun, Huang, Xiang-Yu, Zhao   +4 more
openaire   +2 more sources

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy

Frontiers in Immunology, 2023
Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is an attractive research field in tumor immunotherapy. While CAR is genetically engineered to express certain molecules, it retains the intrinsic ability to recognize tumor cells ...
Kangdi Yang, Yuze Zhao, Guanqun Sun, Xu Zhang, Jinjin Cao, Mingcong Shao, Xijun Liang, Lina Wang   +7 more
doaj   +1 more source