Results 51 to 60 of about 5,478,695 (241)

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Frontiers in Immunology
Allogeneic natural killer (NK) cell therapy has demonstrated significant potential in cancer immunotherapy by harnessing NK cells to target malignancies.
Dong-Hyeon Jo, Dong-Hyeon Jo, Shelby Kaczmarek, Shelby Kaczmarek, Abrar Ul Haq Khan, Abrar Ul Haq Khan, Jannat Pervin, Jannat Pervin, Diana M. Clark, Suresh Gadde, Suresh Gadde, Suresh Gadde, Lisheng Wang, Lisheng Wang, Lisheng Wang, Scott McComb, Scott McComb, Scott McComb, Scott McComb, Alissa Visram, Alissa Visram, Alissa Visram, Seung-Hwan Lee, Seung-Hwan Lee, Seung-Hwan Lee   +24 more
doaj   +1 more source

CAR-NK cell therapy for hematological malignancies

Blood Advances
Abstract Chimeric antigen receptor (CAR)–natural killer (NK) cells represent a novel cell therapy platform distinguished from CAR T cells by their more favorable safety profile, easier off-the-shelf allogeneic manufacturing and consequent scalability, and their innate cytotoxicity without needing previous ...
Gohar S. Manzar, Md Faqrul Hasan, Madison Moore, Silvia Tiberti, Rafet Basar, May Daher   +5 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways

Experimental Hematology & Oncology
Background NK cells engineered to express interleukin-15 (IL-15) and a CD19-targeted chimeric antigen receptor (CAR) have been used to treat patients with relapsed and/or refractory B cell malignances, demonstrating encouraging outcomes and favorable ...
Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu   +14 more
doaj   +1 more source

CD33KO-CD33-mesothelin Loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia

Journal for ImmunoTherapy of Cancer
Background Patients with acute myeloid leukemia (AML) are often older, which brings challenges of endurance and persistent efficacy of autologous chimeric antigen receptor (CAR)-T cell therapies. Allogenic CAR-natural killer (NK) cell therapies may offer
Qi Chen, Qi Zhang, Xin Du, Xiaofan Zhu, Yao Wang, Yi Chen, Fan Zhang, Fangxiao Hu, Dehao Huang, Qitong Weng, Jinyong Wang, Lijuan Liu, Aibin Liang, Jiaxin Wu, Yanhong Liu, Pengcheng Liu, Wenbin Qian, Xiujuan Zheng, Zhiqian Wang, Ziyun Xiao, Yunqing Lin, Leqiang Zhang, Chengxiang Xia, Yanping Zhu, Hanmeng Qi, Yiyuan Shen, Chenyuan Zhang, Jiacheng Xu, Yaoqin Zhao, Tongjie Wang, Mengyun Zhang, Minming Li, Wenyu Yang, Tianyuan Hu   +33 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy

Experimental Hematology & Oncology
Chimeric antigen receptor (CAR)-NK therapy holds great potential for tumor treatment, but current CAR designs are primarily optimized for T cells, raising concerns about their suitability for NK cells. This study compared two dominant CAR designs used in
Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan   +8 more
doaj   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison

Experimental Hematology & Oncology
Background CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying ...
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke   +6 more
doaj   +1 more source

Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

Experimental Hematology & Oncology, 2022
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent achievement in the clinical immunotherapy of hematological malignant tumors, leading to a rapid development of cellular immunotherapy in cancer treatment.
Xiao Wang, Xuejiao Yang, Xiang Yuan, Wenbo Wang, Yueying Wang   +4 more
doaj   +1 more source