Results 31 to 40 of about 24,598 (183)

Higher Rate of Extreme Drug-resistant Klebsiella pneumoniae Infections among Cardiac Patients

Journal of Nepal Health Research Council, 2022
Background: The accelerating rate of carbapenems resistance in Klebseilla pneumoniae isolates has put the treatment option worrisome. The effective strategy to ameliorate this alarming situation is possible through enhancing the combination therapy and ...
Subash Paudel, Pradeep Kumar Shah, Prashanna Adhikari, Sanjay Singh K. C., Upendra Thapa Shrestha   +4 more
doaj   +1 more source

Carbapenemases on the move: it’s good to be on ICEs [PDF]

Mobile DNA, 2018
Abstract The evolution and spread of antibiotic resistance is often mediated by mobile geneticelements. Integrative and conjugative elements (ICEs) are the most abundant conjugativeelements among prokaryotes. However, the contribution of ICEs to horizontal gene transferof antibiotic resistance has been largely ...
João Botelho, Adam P. Roberts, Ricardo León-Sampedro, Filipa Grosso, Luísa Peixe   +4 more
openaire   +5 more sources

Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city

Microbiology Spectrum
Carbapenemase-producing Enterobacterales (CPE) is a diverse group of often multidrug-resistant organisms. Surveillance and control of infections are complicated due to the inter-species spread of carbapenemase-encoding genes (CEGs) on mobile genetic ...
Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke   +15 more
doaj   +1 more source

Acquired bla_VIM and bla_GES Carbapenemase-Encoding Genes in Pseudomonas aeruginosa: A Seven-Year Survey Highlighting an Increasing Epidemiological Threat

Pathogens, 2023
(1) Background: Pseudomonas aeruginosa is a Gram-negative bacterium with several intrinsic and acquired antimicrobial resistance mechanisms. The spread of carbapenemase-encoding genes, an acquired mechanism, enables carbapenem resistance in clinical ...
María Guadalupe Martínez-Zavaleta, Diana Fernández-Rodríguez, Melissa Hernández-Durán, Claudia A. Colín-Castro, María de Lourdes García-Hernández, Noé Becerra-Lobato, Rafael Franco-Cendejas, Luis Esaú López-Jácome   +7 more
doaj   +1 more source

Carbapenemases

, 2019
Carbapenems are usually regarded as the last treatment option for serious infections caused by Gram-negative and Gram-positive microorganisms. Although they are stable to hydrolysis by most β- lactamases, their usage as the last resort antbiotics was seriously compromised by the appearance of carbapenem-hydrolyzing enzymes called carbapenemases.
Bedenić, Branka, Sardelić, Sanda
openaire   +2 more sources

In vitro activity of ceftazidime–avibactam and comparators against Gram-negative bacterial isolates collected in the Asia–Pacific region as part of the INFORM program (2015–2017)

Annals of Clinical Microbiology and Antimicrobials, 2020
Background Antimicrobial resistance among nosocomial Gram-negative pathogens is a cause for concern in the Asia–Pacific region. The aims of this study were to measure the rates of resistance among clinical isolates collected in Asia–Pacific countries ...
Wen-Chien Ko, Gregory G. Stone
doaj   +1 more source

Frequency of Carbapenemase Producing Klebsiella pneumoniae in Makkah, Saudi Arabia

Journal of Microbiology and Infectious Diseases, 2016
Objective: Carbapenemase producing Klebsiella pneumoniae is emerging as an important pathogen worldwide which has alarming clinical threat with serious effects on patients ' outcome.
Mubashir Ahmad Khan, Aftab Faiz
doaj   +1 more source

Carbapenemase-Producing Organisms: A Global Scourge [PDF]

Clinical Infectious Diseases, 2017
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae.
Bonomo, Robert A, Burd, Eileen M, Conly, John, Limbago, Brandi M, Poirel, Laurent, Segre, Julie A, Westblade, Lars F   +6 more
openaire   +4 more sources

In vitro activity of cefiderocol against carbapenemase-producing and meropenem-non-susceptible Gram-negative bacteria collected in the Japan Antimicrobial Resistant Bacterial Surveillance

Journal of Global Antimicrobial Resistance
Objectives: The treatment options available for infections caused by multidrug-resistant Gram-negative pathogens are often limited. Cefiderocol (CFDC) is a novel siderophore cephalosporin that exhibits activity against these pathogens.
Shizuo Kayama, Sayoko Kawakami, Kohei Kondo, Norikazu Kitamura, Liansheng Yu, Wataru Hayashi, Koji Yahara, Yo Sugawara, Motoyuki Sugai   +8 more
doaj   +1 more source

Carbapenemase-Producing Enterobacteriaceae in Spain in 2012 [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT We report the epidemiological impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected, 163 were from the OXA-48 group, 60 were from VIM-1, 8 were from KPC-2, 5 were from IMP, and 1 was from NDM-1.
Oteo-Iglesias, Jesus, Saez, David, Bautista, Veronica, Fernandez-Romero, Sara, Hernández-Molina, Juan Manuel, Perez-Vazquez, Maria, Aracil, Belen, Campos, Jose   +7 more
openaire   +3 more sources