Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]
, 2019 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V. +10 more
core +3 more sources
Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]
, 2020 Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà +92 more
core +1 more source
Conserved unique peptide patterns (CUPP) online platform: peptide-based functional annotation of carbohydrate active enzymes. [PDF]
Nucleic Acids Res, 2020 Barrett K, Hunt CJ, Lange L, Meyer AS.
europepmc +2 more sources
Rumen cellulosomics : divergent fiber-degrading strategies revealed by comparative genome-wide analysis of six ruminococcal strains [PDF]
, 2014 Peer reviewedPublisher ...
Bayer, Edward A +12 more
core +4 more sources
Carbohydrate-Active Enzymes from Alkaliphiles
Journal of Applied Glycoscience, 2003 The market in industrial enzymes for detergents, starch, food, fabric, and so on has been estimated at more than 1600 million US dollars in 1999. The usage of detergent enzymes, such as protease, cellulase, aamylase, and lipase, forms 35% of the world market.
Susumu Ito +8 more
openaire +2 more sources
Modelling Reactions Catalysed by Carbohydrate-Active Enzymes [PDF]
, 2014 AbstractCarbohydrate polymers are ubiquitous in biological systems and their roles are highly diverse, ranging from energy storage over mechanical stabilisation to mediating cell-cell or cell-protein interactions. The functional diversity is mirrored by a chemical diversity that results from the high flexibility of how different sugar monomers can be ...
Kartal, Önder, Ebenhöh, Oliver
openaire +1 more source
Detection of carbohydrate-active enzymes and genes in a spent engine oil-perturbed agricultural soil
Bulletin of the National Research Centre, 2018 Background The purpose of this study is to decipher the diverse carbohydrate metabolism pathways in a spent engine oil-perturbed agricultural soil, enunciate the carbohydrate-active enzymes and genes involved in the process, taxonomically classify the ...
Lateef Babatunde Salam
doaj +1 more source
Metagenomics analysis reveals features unique to Indian distal gut microbiota.
PLoS ONE, 2020 Various factors including diet, age, geography, culture and socio-economic status have a role in determining the composition of the human gut microbiota. The human gut microbial composition is known to be altered in disease conditions.
Kamaldeep Kaur +4 more
doaj +1 more source
How do nematodes transfer phosphorylcholine to carbohydrates? [PDF]
, 2010 An unusual aspect of the biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate. The attachment appears to play an important role in nematode development and, in some parasitic species, in immunomodulation.
Harnett, W., Houston, K.M., Rzepecka, J.
core +1 more source
Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]
, 2014 BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L +7 more
core +2 more sources