Results 81 to 90 of about 109,847 (333)

CARBONIC ANHYDRASE IN Plasmodium falciparum: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA blocking TRANSMISSION COMPOUNDS

Vitae, 2010
Carbonic anhydrase is a metalloenzyme that catalyzes the reversible conversion of CO2 to bicarbonate, an essential metabolic component used by the malaria parasites for de novo synthesis of pyrimidines and the exflagelation of gametocytes inside the ...
Carlos D. AGUDELO R., María CORENA-Mcleod, Sara M. ROBLEDO R.   +2 more
doaj  

Quantitative assessment of specific carbonic anhydrase inhibitors effect on hypoxic cells using electrical impedance assays

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Carbonic anhydrase IX (CA IX) is an important orchestrator of hypoxic tumour environment, associated with tumour progression, high incidence of metastasis and poor response to therapy.
Luciana Stanica, Mihaela Gheorghiu, Miruna Stan, Cristina Polonschii, Sorin David, Dumitru Bratu, Anca Dinischiotu, Claudiu T. Supuran, Eugen Gheorghiu   +8 more
doaj   +1 more source

Hydration Peculiarities of Graphene Oxides with Multiple Oxidation Degrees [PDF]

, 2017
Hydration properties of graphene oxide (GO) are essential for most of its potential applications. In this work, we employ atomistic molecular dynamics simulations to investigate seven GO compositions with different levels of oxygenation. Two atomic charge models for GO are compared: (1) sp2 carbons are purely Lennard-Jones sites; (2) sp2 carbon charges
arxiv   +1 more source

Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]

Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv   +1 more source

Heterocyclic compounds as carbonic anhydrase inhibitor [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2011
The carbonic anhydrases (CAs, EC 4.2.1.1) constitute interesting targets for the design of pharmacological agents useful in the treatment or prevention of a variety of disorders such as, glaucoma, acid-base disequilibria, epilepsy, and other neuromuscular diseases, altitude sickness, edema, and obesity.
Asif Husain, Diwakar Madhesia
openaire   +3 more sources

Benefit from Biomass Boiler Emissions to Increase Greenhouse CO2 Levels for Optimal Growth and Yield in Tomato, Cucumber, and Strawberry

Advanced Energy and Sustainability Research, EarlyView.
Using CO2‐rich polluting gases in greenhouse plant cultivation has proven to be a promising technique for stimulating plants while reducing emissions to the atmosphere. The use of an experimental biofilter proves to be effective in retaining most of the toxic particles. The alteration of physiological and metabolic parameters shows an adaptation of the
Alberto Martinez‐Alonso, Jose Fermoso, Francisco Verdugo, Micaela Carvajal   +3 more
wiley   +1 more source

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

Molecules, 2018
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer.
Srishti Singh, C. Lomelino, Mam Y Mboge, S. Frost, R. McKenna   +4 more
semanticscholar   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

Journal of Medicinal Chemistry, 2019
Carbon monoxide (CO) is a gas endogenously produced in humans, reported to exhibit anti-inflammatory and cytoprotective effects at low concentration. In this context, CO releasing molecules (CORMs) are attracting enormous interest.
Emanuela Berrino, Lisa Milazzo, L. Micheli, D. Vullo, A. Angeli, M. Bozdağ, A. Nocentini, Marta Menicatti, G. Bartolucci, L. di Cesare Mannelli, C. Ghelardini, C. Supuran, F. Carta   +12 more
semanticscholar   +1 more source

Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed.
M. Krasavin, R. Žalubovskis, A. Grandāne, I. Domračeva, P. Zhmurov, C. Supuran   +5 more
semanticscholar   +1 more source