Results 11 to 20 of about 23,292 (261)
mBio, 2016 Peptidoglycan (PG) is an essential structural component of the bacterial cell wall and maintains the integrity and shape of the cell by forming a continuous layer around the cytoplasmic membrane.
Katharina Peters +8 more
doaj +2 more sources
Translational Oncology, 2018 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rate and poor prognosis. However, little is known concerning the molecular mechanism of PDAC at the proteomics level. Here we report a proteomics analysis of
Yang Song +10 more
doaj +2 more sources
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids [PDF]
Molecular Biology of the Cell, 2014 The posttranslational modification of carboxy-terminal tails of tubulin plays an important role in the regulation of the microtubule cytoskeleton. Enzymes responsible for deglutamylating tubulin have been discovered within a novel family of mammalian ...
Andrieux, Annie +10 more
core +6 more sources
Developmental and Comparative Immunology, 2021 Metallo-carboxypeptidases are exopeptidases with diverse expression and function, found in all kingdoms of life from bacteria to mammals. One of them, the carboxypeptidase A3 (CPA3), has become an important component of the mammalian immune system by its
Srinivas Akula +3 more
semanticscholar +1 more source
Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides
Cell Reports, 2020 Summary: The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival. During growth, bacteria remodel their PG, releasing fragments that are predominantly re-internalized and recycled.
Sara B. Hernández +3 more
doaj +1 more source
Antibiotics, 2016 The Gram-positive bacterium Staphylococcus carnosus (S. carnosus) TM300 is an apathogenic staphylococcal species commonly used in meat starter cultures.
Julia Deibert +4 more
doaj +1 more source
Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues
iScience, 2022 Summary: Understanding the molecular principles that govern the composition of the MHC-I immunopeptidome across different primary tissues is fundamentally important to predict how T cells respond in different contexts in vivo. Here, we performed a global
Peter Kubiniok +13 more
doaj +1 more source
Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
Cell Reports, 2023 Summary: Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through cGAS-stimulator of interferon genes (STING)-TBK1-IRF3-type I interferon (IFN-I) signalingcascade.
Gui Qian +17 more
doaj +1 more source
Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]
, 2003 Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P. +2 more
core +2 more sources
BRS1 mediates plant redox regulation and cold responses
BMC Plant Biology, 2021 Background Brassinosteroid-insensitive 1 suppressor 1 (BRS1) is a serine carboxypeptidase that mediates brassinosteroid signaling and participates in multiple developmental processes in Arabidopsis. However, little is known about the precise role of BRS1
Dongzhi Zhang +4 more
doaj +1 more source