Results 31 to 40 of about 23,292 (261)

The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights

Biomolecules, 2022
Complications to preterm birth are numerous, including the presence of a patent ductus arteriosus (PDA). The biological understanding of the PDA is sparse and treatment remains controversial.
Anna Sellmer, Tine Brink Henriksen, Johan Palmfeldt, Bodil Hammer Bech, Julie Astono, Tue Bjerg Bennike, Vibeke Elisabeth Hjortdal   +6 more
doaj   +1 more source

Zebrafish Cytosolic Carboxypeptidases 1 and 5 Are Essential for Embryonic Development*

Journal of Biological Chemistry, 2013
Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs.
Peter J. Lyons, M. Sapio, L. Fricker
semanticscholar   +1 more source

Validation process of EDTA for infusion/ injection with ceftriaxone and sulbactam

Journal of Applied Pharmaceutical Research, 2021
The validation of the manufacturing process to produce ceftriaxone/ sulbactam with EDTA1.5 g/ vial powder for solution for injection/ infusion. Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall.
Md. Semimul Akhtar, Akash Babu, Sudip Kumar Mandal   +2 more
doaj   +1 more source

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies [PDF]

, 2014
A potential cytosolic metallocarboxypeptidase from Burk­holderia cenocepacia has been crystallized and a synchrotron-radiation microfocus beamline allowed the acquisition of diffraction data to 1.9 Å resolution.
An, Bond, Chen, Cho, Christianson, Christianson, Cruickshank, Dawson, Eadsforth, Emsley, Engh, Evans, Faming, Fauman, Gardell, Gomis-Rüth, Hunter, Joosten, Joosten, Kabsch, Kalinina, Kim, Kimura, Krissinel, Krissinel, Leslie, Mangani, McCoy, Moynie, Murshudov, Otero, Painter, Rawlings, Robbie P. Joosten, Rodriguez de la Vega, Rogowski, Sahab, Schormann, Sievers, Thomas C. Eadsforth, Vadim Rimsa, William N. Hunter, Winn, Winstanley   +43 more
core   +1 more source

Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection

Life Science Alliance, 2022
Using high-resolution structure, we have characterized the substrate specificity of Aedes aegypti procarboxypeptidase B1 and provided mechanistic insights into the binding and inhibition of DENV Metallocarboxypeptidases play critical roles in the ...
Edem Gavor, Yeu Khai Choong, Nikhil Kumar Tulsian, Digant Nayak, Fakhriedzwan Idris, Hariharan Sivaraman, Donald Heng Rong Ting, Alonso Sylvie, Yu Keung Mok, R Manjunatha Kini, J Sivaraman   +10 more
doaj   +1 more source

Identification of Tubulin Deglutamylase among Caenorhabditis elegans and Mammalian Cytosolic Carboxypeptidases (CCPs)*♦

Journal of Biological Chemistry, 2010
Tubulin polyglutamylation is a reversible post-translational modification, serving important roles in microtubule (MT)-related processes. Polyglutamylases of the tubulin tyrosine ligase-like (TTLL) family add glutamate moieties to specific tubulin ...
Yoshishige Kimura, Nobuya Kurabe, K. Ikegami, Koji Tsutsumi, Y. Konishi, O. I. Kaplan, H. Kunitomo, Y. Iino, O. Blacque, M. Setou   +9 more
semanticscholar   +1 more source

Production of the Antihypertensive Peptide Tyr-Pro from Milk Using the White-Rot Fungus Peniophora sp. in Submerged Fermentation and a Jar Fermentor

Dairy, 2021
In order to evaluate the blood pressure-lowering peptide Tyr-Pro (YP) derived from casein, we wanted to develop an efficient fermentation method. Therefore, we chose to use a jar fermentor for this purpose.
Kenji Okamoto, Ryosuke Ito, June Hayashi, Mizuki Tagawa   +3 more
doaj   +1 more source

Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]

, 2016
Comparison of performance of the three approaches using known 250 peptidoglycan hydrolases.
Ashok K. Sharma, Darshan B. Dhakan, Harish K., Sanjiv Kumar, Vineet K. Sharma   +4 more
core   +10 more sources

Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]

, 2018
Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core   +3 more sources

Altering Enzymatic Activity: Recruitment of Carboxypeptidase Activity into an RTEM β-Lactamase/Penicillin-Binding Protein 5 Chimera [PDF]

, 1990
The D-Ala-D-Ala carboxypeptidases/transpeptidases (penicillin-binding proteins, PBPs) share considerable structural homology with class A β-lactamases (EC 3.5.2.6), although these β-lactamases have no observable D-Ala-D-Ala carboxypeptidase activity ...
Chang, Yie-Hwa, Labgold, Marc R., Richards, John H.   +2 more
core