Results 1 to 10 of about 336,163 (140)

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1 [PDF]

Redox Biology
Cardiac fibrosis remains an unresolved clinical issue in patients with heart diseases. CircRNAs have emerged as potential targets for treatment of heart diseases.
Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, Wenchao Wu, Zhichao Zhou, Xiaoqiang Tang, Xiaojing Liu   +13 more
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LncRNA nonnmmut065573 promotes post-myocardial infarction cardiac fibrosis and activates the TGF-β1/ZEB1 pathway [PDF]

Cell Regeneration
Cardiac fibrosis following myocardial infarction (MI) is a critical determinant of progressive cardiac dysfunction, yet the underlying mechanisms driving this pathological process remain incompletely understood.
Chaowei Hu, Lijie Han, Zhiyong Du, Huahui Yu, Yunhui Du, Linyi Li, Haili Sun, Yu Wang, Xiaoqian Gao, Xuechun Sun, Zihan Zhang, Lanqing Liu, Yanjing Zhang, Yanwen Qin   +13 more
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Revolutionizing cardiac fibrosis treatment: the potential of personalized CAR T-cell therapy [PDF]

Cardio-Oncology
Cardiac fibrosis, a condition characterized by the deposition of excess collagen in the cardiac tissue, is a major complication of various cardiovascular diseases, including myocardial infarction, hypertension, and different types of cardiomyopathies ...
Soroush Taherkhani, Maryam Honardoost, Negar Dokhani, Atousa Janzadeh   +3 more
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Ubiquitin proteasome system in cardiac fibrosis [PDF]

Journal of Advanced Research
Background: Cardiac fibrosis, including reactive fibrosis and replacement fibrosis, is a common pathological process in most cardiovascular diseases.
Linqi Zeng, Xiaokai Zhang, Zihang Huang, Shuai Song, Mohan Li, Tongyao Wang, Aijun Sun, Junbo Ge   +7 more
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Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics

Frontiers in Molecular Biosciences, 2022
Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues. Elasticity is required in the heart for properly pumping blood to the whole body. Dysregulated ECM remodeling causes fibrosis in the cardiac tissues.
Vivek Sarohi, Vivek Sarohi, Sanchari Chakraborty, Sanchari Chakraborty, Trayambak Basak, Trayambak Basak   +5 more
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Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Microbiology Spectrum, 2022
Cardiac fibrosis is an integral aspect of every form of cardiovascular diseases, which is one of the leading causes of death worldwide. It is urgent to explore new effective drugs and treatments.
Jiaqi Wang, Jiahuan Chen, Linquan Li, Huanyu Zhang, Daxin Pang, Hongsheng Ouyang, Xuemin Jin, Xiaochun Tang   +7 more
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Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway.

PLoS ONE, 2022
Cardiac fibrosis is a common cause of most cardiovascular diseases. Leonurine, an alkaloid from Herba leonuri, had been indicated to treat cardiovascular diseases due to its cardioprotective effects.
Zhaoyi Li, Keyuan Chen, Yi Zhun Zhu
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Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

Cardiology and Therapy, 2023
Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and cytokines play indispensable roles in cardiac fibrosis. Many signaling pathways participate in cardiac fibrosis
Xuejing Yu
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Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Molecules, 2023
(1) Background: Heart failure (HF) is the final stage of multiple cardiac diseases, which have now become a severe public health problem worldwide.
Wenqi Li, Shuwen Zhu, Jing Liu, Zhigang Liu, Honggang Zhou, Qianyi Zhang, Yue Yang, Li Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Cheng Yang   +14 more
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Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities

Molecules, 2022
Cardiac fibrosis is a common pathophysiologic process in nearly all forms of heart disease which refers to excessive deposition of extracellular matrix proteins by cardiac fibroblasts.
Ruiqiang Qi, E. Lin, Juan Song, Yan Wang, Ling Lin   +4 more
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