Results 11 to 20 of about 336,282 (259)
Biology Direct, 2022 Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear.
Tingwei Peng +12 more
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Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis
Frontiers in Cardiovascular Medicine, 2022 Cardiac fibrosis is a key pathological link of various cardiovascular diseases to heart failure. It is of great significance to deeply understand the development process of cardiac fibrosis and the cellular and molecular mechanisms involved.
Siyuan Hu +14 more
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Frontiers in Pharmacology, 2020 Rationale: Cardiac fibrosis is observed in nearly every form of myocardial disease. Long non-coding RNAs (lncRNAs) have been shown to play an important role in cardiac fibrosis, but the detailed molecular mechanism remains unknown.Object: We aimed at ...
Bihui Luo +9 more
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ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Frontiers in Cardiovascular Medicine, 2022 Myocardial infarction or pressure overload leads to cardiac fibrosis, the leading cause of heart failure. ADAMTS8 (A disintegrin and metalloproteinase with thrombospondin motifs 8) has been reported to be involved in many fibrosis-related diseases ...
Yafang Zha +6 more
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Modulation of Cardiac Fibrosis in and Beyond Cells
Frontiers in Molecular Biosciences, 2021 The extracellular matrix (ECM) plays important roles in maintaining physiological structure and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of ECM, including both fibrillar (collagens I and III) and non-fibrillar ...
Dong Fan, Zamaneh Kassiri
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Micro-RNA family that modulates fibrosis and uses thereof [PDF]
, 2017 The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
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LncRNA CFRL aggravates cardiac fibrosis by modulating both miR-3113-5p/CTGF and miR-3473d/FN1 axis
iScience, 2023 Summary: Cardiac fibrosis is a major type of adverse remodeling, predisposing the disease progression to ultimate heart failure. However, the complexity of pathogenesis has hampered the development of therapies.
Yue Cui +9 more
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The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila [PDF]
, 2018 Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure.
Hartley, Paul S. +3 more
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Acta Pharmaceutica Sinica B, 2019 Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Dan Xiao +14 more
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Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. [PDF]
PLoS ONE, 2016 Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of ...
Jody Groenendyk +6 more
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