Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study [PDF]
, 2017 Background: Several fatal cases of bodybuilders, following a myocardial infarction after long exposure to androgenicanabolic steroids (AAS), are reported. In recent years, evidence has emerged of cases of heart failure related to AAS consumption, with no
Cecchi, Rossana +7 more
core +1 more source
Targeting GPCRs to treat cardiac fibrosis
Frontiers in Cardiovascular Medicine, 2022 Cardiac fibrosis occurs ubiquitously in ischemic heart failure, genetic cardiomyopathies, diabetes mellitus, and aging. It triggers myocardial stiffness, which impairs cardiac function, ultimately progressing to end-stage heart failure and increased ...
Hao Zhang +2 more
doaj +1 more source
Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons. [PDF]
, 2017 Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown.
Ambale-Venkatesh, Bharath +9 more
core +2 more sources
Frontiers in Pharmacology, 2023 Cardiac fibrosis is a serious public health problem worldwide that is closely linked to progression of many cardiovascular diseases (CVDs) and adversely affects both the disease process and clinical prognosis.
Chunjun Li +3 more
doaj +1 more source
Myocardial fibrosis in stroke survivors [PDF]
, 2015 Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac death ...
Allgar, V. +6 more
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TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]
, 2017 Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz +10 more
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Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances
Frontiers in Physiology, 2020 Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu +4 more
doaj +1 more source
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco +15 more
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Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis
Pharmacological Research, 2023 Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety of cardiovascular diseases and greatly influences heart structure and function, progressively leading to the development of heart failure.
Weikang Liu +8 more
doaj +1 more source
Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue [PDF]
, 2017 Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias.
Panfilov, Alexander +2 more
core +2 more sources