Results 111 to 120 of about 21,606,107 (313)

Caspase-1 Deficiency Modulates Adipogenesis through Atg7-Mediated Autophagy: An Inflammatory-Independent Mechanism

Biomolecules
Obesity stands as a significant risk factor for type 2 diabetes, hyperlipidemia, and cardiovascular diseases, intertwining increased inflammation and decreased adipogenesis with metabolic disorders.
Yumeng Wang, Gaojun Chen, Min Xu, Yewei Cui, Weijiong He, Hongxiang Zeng, Ting Zeng, Rui Cheng, Xi Li   +8 more
doaj   +1 more source

Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

Journal of Inflammation Research, 2022
Jingjing Liu,1– 3 Guoqing Fan,1– 3 Ningning Tao,4 Tieying Sun1,2 1Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing ...
Liu J, Fan G, Tao N, Sun T
doaj  

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Caspase-3 participates in the E10.5 lethality of RIPK1 D325A mutant mice while neither intrinsic apoptosis nor pyroptosis is required.

, 2021
(A) Western blot analysis for Apaf-1 expression in embryos of indicated genotypes. (B) IF staining of E10.5 YS of indicated genotypes with anti-PECAM (red) and anti-ASC (green) or anti-Cl.GSDMD (green) antibodies. Scale bars, 50 μm.
Ye-hsuan Sun (11338002), Lang Li (91927), Chenchen Ruan (11337999), Wenke Shi (11338005), Yingying Zhang (42910), Jiahuai Han (247944), Tao Han (22342), Wei Han (151406), Yuxia Zhang (318750), Su-qin Wu (11338008), Kai Huang (3983), Jun Liu (42548), Jing Song (188926)   +12 more
core   +1 more source

Inhibitors of Caspase-1, Caspase-3, Caspase-6 and Caspase-8 block silica-induced pyroptosis.

, 2022
Related to Fig 4. a, Images and cell viability of WT, Nlrp3-/-, Caspase-1-/-, Gsdmd-/-, Gsdme-/- and Gsdmd-/-Gsdme-/- BMDMs pretreated with the indicated caspase inhibitors and stimulated with silica. Arrowheads indicate pyroptotic cells.
Yujie Zou (408340), Yaqiong Tian (6309854), Peiliang Shi (2617767), Lulu Kang (684986), Ji Zhang (70438), Visarut Codey Buranasudja (14209915), Jinghong Dai (13848544), Jingwen Pei (5626415), Xiang Gao (4077), Hourong Cai (6309875), Zhaoyu Lin (170763), Yufang Wang (105742), Jingyu Chen (3571688)   +12 more
core   +1 more source

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

European Journal of Immunology
Caspase-1 location in cells has been studied with fluorochrome-labeled inhibitors of caspase-1 (FLICA reagents). We report that FLICA reagents have limited cell-membrane permeability. This impacts experimental design as cells with intact membranes, including caspase-1 knockout cells, are not appropriate controls for cells with inflammasome-induced ...
Sara J Thygesen, Sabrina S Burgener, Prerna Mudai, Mercedes Monteleone, Dave Boucher, Vitaliya Sagulenko, Kate Schroder, Katryn J Stacey   +7 more
openaire   +4 more sources

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Retrovirology
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune tissue reconstitution remain a challenge for ...
Alex J. Holloway, Tais B. Saito, Kubra F. Naqvi, Matthew B. Huante, Xiuzhen Fan, Joshua G. Lisinicchia, Benjamin B. Gelman, Janice J. Endsley, Mark A. Endsley   +8 more
doaj   +1 more source

Caspase-11 controls pyroptosis of lung epithelial cells.

, 2018
(A) TC-1 cells were infected with B. thailandensis or the bsaZ mutant in presence or absence of IFNγ. Active caspase-11 was pulled-down from cell lysates using Biotin-VAD-FMK and detected by immunoblot.
Fabio Re (189981), Jinyong Wang (112096), Manoranjan Sahoo (189969), Jonathan Warawa (5264573), Hector Cordero (5264579), Kelly Deobald (5264576), Louis Lantier (499627)   +6 more
core   +1 more source

Caspase-1 Builds a New Barrier to Infection [PDF]

Cell, 2006
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected by certain pathogens. Work by now reveals a surprising new function for caspase-1: the stimulation of membrane biogenesis to repair damage caused by bacterial pore-forming toxins. Thus, caspase-1 may promote host cell survival as a means of resistance to
openaire   +2 more sources