Caspase-11–Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic SteatohepatitisSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background: Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH.
Yingwei Zhu +6 more
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Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS [PDF]
eLifeInflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes.
Daniel C Akuma +9 more
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Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus [PDF]
MedCommNoncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis remains unclear ...
Yue Xin +4 more
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LincRNA-EPS inhibits caspase-11 and NLRP3 inflammasomes in gingival fibroblasts to alleviate periodontal inflammation. [PDF]
Cell Prolif, 2023 To investigate the effects of long intergenic noncoding RNA‐erythroid prosurvival (lincRNA‐EPS) on periodontal inflammation mediated by inflammasomes and to explore its mechanism.
Hu A, Xiao F, Wu W, Xu H, Su J.
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Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages. [PDF]
Front Immunol, 2023 Introduction Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma.
Drummer C +19 more
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Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes. [PDF]
EMBO J, 2023 Moraxella catarrhalis is an important human respiratory pathogen and a major causative agent of otitis media and chronic obstructive pulmonary disease. Toll‐like receptors contribute to, but cannot fully account for, the complexity of the immune response
Enosi Tuipulotu D +28 more
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Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. [PDF]
Nat Immunol, 2022 Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome.
Moretti J +9 more
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Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages. [PDF]
Front Immunol, 2023 Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that control fatty acid and cholesterol metabolism. As the major SREBP isoform in macrophages, SREBP1a is also required for inflammatory and phagocytotic functions. However,
Cheng Y +4 more
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Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages. [PDF]
Int J Mol Sci, 2023 We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the components responsible for the anti-inflammatory role remained unclear. This study
Cho HJ, Kim E, Yi YS.
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The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis [PDF]
Journal of Inflammation Research, 2023 Pengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic
Jiao P, Li Z, Li B, Jiao X
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