Mycobacterium tuberculosis PE_PGRS19 Induces Pyroptosis through a Non-Classical Caspase-11/GSDMD Pathway in Macrophages. [PDF]
Microorganisms, 2022 The PE/PPE protein family commonly exists in pathogenic species, such as Mycobacterium tuberculosis, suggesting a role in virulence and its maintenance. However, the exact role of most PE/PPE proteins in host–pathogen interactions remains unknown.
Qian J +6 more
europepmc +2 more sources
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway. [PDF]
Ren Fail, 2022 Acute kidney injury (AKI) is a serious condition with high mortality. The most common cause is kidney ischemia/reperfusion (IR) injury, which is thought to be closely related to pyroptosis.
Cai Q +7 more
europepmc +2 more sources
Gemfibrozil mitigates caspase-11-driven myocardial pyroptosis in ischemia/reperfusion injury in mice [PDF]
Journal of Molecular and Cellular Cardiology PlusThe size of the infarct area following acute myocardial infarction (AMI) is a critical prognostic factor. Caspase-11-dependent pyroptosis has been implicated as a key mechanism driving cardiomyocyte death after AMI.
Tetsuro Marunouchi +3 more
doaj +2 more sources
Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases. [PDF]
Int J Mol Sci, 2022 An inflammatory response consists of two consecutive steps: priming and triggering, to prepare and activate inflammatory responses, respectively. The cardinal feature of the triggering step is the activation of intracellular protein complexes called ...
Yi YS.
europepmc +2 more sources
Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury [PDF]
Molecular MedicineBackground Retinal ischemia/reperfusion (IR) injury is a common pathological process in many ophthalmic diseases. Interleukin-1β (IL-1β) is an important inflammatory factor involved in the pathology of retinal IR injury, but the mechanism by which IL-1β ...
Yong Wan +5 more
doaj +2 more sources
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
Nature Communications, 2016 Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute.
Teresa L. M. Thurston +7 more
doaj +2 more sources
Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1
Cell Reports, 2014 Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of ...
Bénédicte F. Py +10 more
doaj +5 more sources
El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes [PDF]
Frontiers in Immunology, 2019 Vibrio cholerae is a Gram-negative enteropathogen causing potentially life-threatening cholera disease outbreaks, for which the World Health Organization currently registers 2–4 million cases and ~100.000 cholera-associated deaths annually worldwide ...
Michail Mamantopoulos +14 more
doaj +3 more sources
PLoS Pathogens, 2020 We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs).
Shauna M Crowley +6 more
doaj +2 more sources
Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production [PDF]
Frontiers in ImmunologyIntroductionKlebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying K.
Yuqi Zhou +8 more
doaj +2 more sources