Results 251 to 260 of about 467,366 (285)

Structural insights into cytokine cleavage by inflammatory caspase-4

Nature, 2023
Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines1,2. Despite the biological importance, the structural basis for inflammatory caspase-mediated cytokine processing has remained unclear.
Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P. Gygi, Hao Wu, Jonathan C. Kagan   +6 more
openaire   +2 more sources

Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress

Biochemical and Biophysical Research Communications, 2022
Calpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is
Yusaku Chukai, Ginga Ito, Masahide Konno, Yuri Sakata, Taku Ozaki   +4 more
openaire   +2 more sources

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

European Journal of Immunology, 2015
Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL‐1β production; however the mechanism underlying this process is not yet confirmed.
Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.   +14 more
openaire   +3 more sources

Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria

2023
The non-canonical inflammasome pathway functions as the primary cytosolic innate immune detection mechanism for Gram-negative bacterial lipopolysaccharide (LPS) in human and mouse cells and controls the proteolytic activation of the cell death executor gasdermin D (GSDMD). The main effectors of this pathways are the inflammatory proteases caspase-11 in
Marisa, Dilucca, Petr, Broz
openaire   +2 more sources

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

Nature, 2023
The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11; hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce pyroptosis1,2. Whereas caspase-1 processes IL-1β and IL-18 for maturation3-6, no cytokine target has been firmly established for lipopolysaccharide-activated caspase-4/5/117-9. Here we show that
Xuyan Shi, Qichao Sun, Yanjie Hou, Huan Zeng, Yong Cao, Mengqiu Dong, Jingjin Ding, Feng Shao   +7 more
openaire   +2 more sources

Arsenic Trioxide Induces Apoptosis in Molt-4 Cell Lines: Caspase 8-Dependent and Caspase 3-Independent.

Blood, 2004
Abstract Arsenic Trioxide (As2O3) has been used successfully in the treatment of patients with relapsed or refractory acute promyelocytic leukemia (APL) without severe marrow suppression. Currently, the action of As2O3 on many other hematopoietic malignancies is under investigation.
Wenbin Qian, Wanmao Ni, Junqing Liu
openaire   +1 more source

Oligomerized Ced-4 Kills Budding Yeast through a Caspase-Independent Mechanism

Biochemical and Biophysical Research Communications, 1999
In Caenorhabdtis elegans, Ced-3, Ced-4, and Ced-9 are components of a cell suicide program. Ced-4 facilitates the proteolytic activation of the caspase, Ced-3, while Ced-9 opposes Ced-3/Ced-4 killing. To examine the interactions among these proteins they were expressed in Saccharomyces cerevisiae.
W, Tao, D W, Walke, J I, Morgan
openaire   +2 more sources

Both dimerization and interdomain processing are essential for caspase-4 activation

Biochemical and Biophysical Research Communications, 2007
A subgroup of caspase family of inflammatory caspases (-1, -4, -5, -11, and -12) play important role during cytokine maturation and inflammation but their regulation is not well understood as much as the initiator and effector caspases. Here, the biochemical mechanism of caspase-4 activation is elucidated.
Pratap, Karki, Giri Raj, Dahal, Il-Seon, Park   +2 more
openaire   +2 more sources

[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].

Zhonghua yi xue za zhi, 2017
To study apoptosis and expression of Caspase 3 and Caspase 4 in temporal lobe neurocytes of refractory human temporal lobe epilepsy (TLE).The temporal tissue samples were obtained from 30 cases of refractory TLE (TLE group) and 10 cases of brain trauma (contrast group) between January 1993 and May 2008.
R T, Lin, R R, Cai, P F, Zhang, Y X, Lin
openaire   +1 more source

Caspase-4 and Caspase-5

2013
Junjun Gao, James A. Wells
openaire   +1 more source