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Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
Journal of molecular biology, 2000Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target. Caspases are cysteine proteases that are specific for substrates with an aspartic acid residue at the P(1) position and have an optimal recognition motif that incorporates four amino acid residues N-terminal to the ...
H, Blanchard +5 more
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Die Rolle der Caspase-4 und -5 in renalen Schädigungsmodellen
2021Hintergrund und Ziele: Die murine Caspase-11 und ihre humanen Gegenstücke, Caspase-4 und -5, sind bei Entzündungsreaktionen an der Regulation von Zelluntergang und damit verbunden an der Freisetzung von Interleukin-1a beteiligt. Während die Aktivierung der Caspasen durch zytosolisches Lipopolysaccharid sehr gut untersucht ist, existieren bislang nur ...
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SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation
Signal Transduction and Targeted Therapy, 2020Jun Shen, Shi Zhengli, Peng Zhou
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature, 2015Nobuhiko Kayagaki +2 more
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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Nature, 2019Lars M Schiffmann, , Martin Krönke
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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Nature, 2004Sanjeev Mariathasan +2 more
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Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome
Nature Catalysis, 2020Bas J H M Rosier +2 more
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