Results 221 to 230 of about 170,565 (294)

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Pyroptosis-induced tissue damage in kidney disease. [PDF]

Ren Fail
Zhang Z, Li X, Han Y, Zhang M.
europepmc   +1 more source

Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis [PDF]

, 1997
L. Miguel Martins, Peter W. Mesner, Timothy Kottke, Guriqbal S. Basi, Sukanto Sinha, Jay S. Tung, Phyllis A. Svingen, Benjamin J. Madden, Atsushi Takahashi, Daniel McCormick, William C. Earnshaw, Scott H. Kaufmann   +11 more
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines. [PDF]

Chem Biodivers
Maistry L, Gerrano AS, Mellem JJ.
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages. [PDF]

Front Immunol
Gan YQ, Cai YW, Liang XW, Wang LZ, Shi FL, Sun N, Li YP, Xu R, Hu B, Zha QB, He XH, Wong TS, Li JH, Ouyang DY.   +13 more
europepmc   +1 more source

Distinct Differences In Alveolar Epithelial Cell Death Signalling Between Models Of Ards [PDF]

, 2017
Nakamura, H, Patel, BV, Romano, R, Takata, M, Yao, K   +4 more
core  

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives. [PDF]

Biomolecules
Eckhart L, Sachslehner AP, Steinbinder J, Fischer H.   +3 more
europepmc   +1 more source