Results 151 to 160 of about 143,203 (306)

Evolutionary diversification and immunoprofiling of cathepsin L toolkit in common carp. [PDF]

Front Cell Infect Microbiol
Nayak S, Kyslík J, Majstorović J, Dobai T, Žánová V, Pecková H, Korytář T, Bartošová-Sojková P.   +7 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Development of Cathepsin B‑Activatable Cell-Penetrating Peptides for Tumor Targeting. [PDF]

ACS Pharmacol Transl Sci
Kuhne K, Strohbach L, Neuber C, Wodtke R, Ruiz-Gómez G, Belter B, Brandt F, Gluhacevic von Krüchten L, Keller M, Pisabarro MT, Kopka K, Pietzsch J, Löser R.   +12 more
europepmc   +1 more source

Proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches [PDF]

, 1991
A Billing, A Billing, B Blauhut, C Gippner-Steppert, D Inthorn, D Nast-Kolb, H Hoffmann, H Vinazzer, I Assfalg-Machleidt, I Schraufstatter, JI Weitz, K-H Duswald, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Siebeck, M Siebeck, M Spannagl, MD Wewers, RE Jordan, S Idell, S Neumann, TE Emerson, U Obertacke, YT Wachtfogel, YT Wachtfogel   +30 more
core   +1 more source

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

CD74-Targeted Cathepsin-Inhibitor Antibody-Drug Conjugate Triggers Apoptosis in DLBCL. [PDF]

Cells
Abd-Elrahman I, Khairi N, Sinai-Turyansky R, Zlotber I, Perlman R, Merquiol E, Blum G, Ben Yehuda D.   +7 more
europepmc   +1 more source

Cathepsin [PDF]

, 2020
openaire   +1 more source

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin-S Inhibitor, in Healthy Adult Subjects. [PDF]

Clin Transl Sci
Kojima T, Chen W, Smulders R, Stanhope S, Kowalski D, Heo N, Moy S, Goldston A, Han D, Zhu T.   +9 more
europepmc   +1 more source

Specific proteins of inflammatory cells and alpha1-proteinase inhibitor in alveolar epithelial lining fluid of polytraumatized patients [PDF]

, 1991
Jochum, Marianne, Sturm, J. A.
core   +1 more source