The FEBS Journal, EarlyView.Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu +16 more
wiley +1 more source
The role of inflammatory proteins in mediating the effect of cathepsins on cholelithiasis: A mendelian randomization study. [PDF]
Sci ProgYuan T, Wang T.
europepmc +1 more source
Chronic Excessive Exercise Aggravates Apical Periodontitis in Mice
International Endodontic Journal, EarlyView.ABSTRACT Aim To investigate the effects of overtraining on the development of apical periodontitis (AP) in mice. Methodology Sixty 6‐week‐old male C57BL/6 mice were allocated to six groups: sedentary without AP (SED); sedentary with AP (SED AP); aerobic training without AP (AERO); aerobic training with AP (AERO AP); overtraining without AP (OVER); and ...
Andréia Bosco Boaventura +6 more
wiley +1 more source
A Dual-Ligand PDC Co-Targeting FOLR1 and c-Met Enhances Tumor Accumulation and Antitumor Efficacy in Ovarian Cancer. [PDF]
Cancers (Basel)Cai H +5 more
europepmc +1 more source
In Vitro Evaluation of Bond Strength of Adhesive Systems to Dentin and Stability of the Hybrid Layer
Journal of Esthetic and Restorative Dentistry, EarlyView.ABSTRACT Objective Contemporary dental adhesives demonstrate strong durable adhesion to enamel while long‐term bonding stability to dentin remains uncertain. This in vitro study aimed to compare conventional dentin conditioning protocols supplemented with protease inhibition and chelate‐based conditioning protocols. Materials and Methods Four groups of
Ana Torres Muñoz +4 more
wiley +1 more source
The Lysosome-Cathepsin Axis in Pancreatic Cancer: Mechanisms of Stromal Remodeling, Immune Evasion, and Therapy Resistance. [PDF]
BiomoleculesMazej Jeram N +3 more
europepmc +1 more source
Journal of Esthetic and Restorative Dentistry, EarlyView.ABSTRACT Objectives To evaluate the effect of reduced dentin etching time on the clinical performance of two universal adhesive systems in noncarious cervical lesions (NCCLs). Methods A total of 144 NCCLs restorations were randomly placed in 36 participants according to four experimental groups: SUP5 (Scotchbond Universal Plus adhesive [pH ≈2.5–2.7 ...
Mario Felipe Gutiérrez +4 more
wiley +1 more source
The promising role of cathepsins as biomarkers and therapeutic targets in glioblastoma. [PDF]
Discov OncolCalcaterra E +10 more
europepmc +1 more source
Genetic Susceptibility to Periodontitis
Journal of Periodontal Research, EarlyView.Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley +1 more source
Transcutaneous auricular vagus nerve stimulation alleviates chronic heart failure by targeting cathepsin K/p53-mediated ferroptosis. [PDF]
Biol DirectZhao L +9 more
europepmc +1 more source