Results 181 to 190 of about 143,203 (306)

The protease cathepsin K can debulk the cancer glycocalyx. [PDF]

J Biol Chem
Kuo A, Tender GS, Chow WD, Riley NM, Wen KC, Park S, Paek JH, Roberts DS, Peltan EL, Paszek MJ, Bertozzi CR.   +10 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Intralysosomal pathogens differentially influence the proteolytic potential of their niche. [PDF]

Infect Immun
Bird LE, Xu B, Thomas DR, McGowan ENS, Newton P, Scott NE, McConville MJ, Edgington-Mitchell LE, Newton HJ.   +8 more
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury. [PDF]

J Clin Invest
Wang M, Huang Z, Du Z, Shan J, Ye Q, Lu L, Jiang M, Xu F, Liu Z, Fulton DJ, Leak RK, Razani B, Chen J, Hu X.   +13 more
europepmc   +1 more source

Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers [PDF]

, 2017
Choi, Young-Jun, et al.,, Fischer, Peter U, Hallsworth-Pepin, Kymberlie, McNulty, Samantha N, Mitreva, Makedonka, Rosa, Bruce A, Tyagi, Rahul   +7 more
core   +1 more source

Inhibition of proteinases with recombinant Eglin c during experimental Escherichia coli septicemia in the pig [PDF]

, 1989
Fritz, Hans, Hoffmann, H., Jochum, Marianne, Siebeck, Matthias   +3 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Time-resolved simultaneous imaging of mitochondrial reactive oxygen species and lysosomal permeabilization to determine organelle-centred cell death. [PDF]

Redox Rep
Jain Tiffee PJ, Sivasailam A, Kumar KS, Varghese Jancy S, Geetha Jayaprasad A, Halikar AM, Rather AA, Satheesan Sinivirgin N, Anurup KG, Santhoshkumar TR.   +9 more
europepmc   +1 more source

A Placenta Derived C-Terminal Fragment of beta-Hemoglobin With Combined Antibacterial and Antiviral Activity

, 2020
Bauer, R., Conzelmann, C., Forssmann, W., Gačanin, J., Gerbl, F., Groß, R., Hagemann, B., Kirchhoff, F., Krüger, F., Mankertz, A., Münch, J., Olari, L., Preising, N., Rodríguez, A., Ruiz-Blanco, Y., Rücker-Braun, E., Sanchez-Garcia, E., Santibanez, S., Sauter, D., Spellerberg, B., Stenger, S., Ständker, L., Walther, P., Weil, T., Wiese, S.   +24 more
core   +1 more source