Results 161 to 170 of about 102,381 (252)

S1 Guideline: Therapy of generalized pustular psoriasis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner, Neda Cramer, Sascha Gerdes, Ulrike Hüffmeier, Andreas Körber, Kai Krause, Christian Kromer, Katharina Antonia Langen, Sandra Philipp, Knut Schäkel, Michael P. Schön, Michael Schultheis, Lukas Sollfrank, Petra Staubach, Michael Sticherling, Johannes Wohlrab, Dagmar Wilsmann‐Theis, Cornelia Paul   +17 more
wiley   +1 more source

From Cysteamine to Pepstatin A: Targeting Cathepsin D To Improve Bone Health in Cystinosis. [PDF]

Int J Biol Sci
Battafarano G, Rossi M, Pagliarosi O, Di Giuseppe L, Di Gregorio J, Terreri S, De Stefanis C, Pezzullo M, Di Giovamberardino G, Vernocchi P, Marzano V, Putignani L, D'Amico J, Piemonte F, Taranta A, Emma F, Del Fattore A.   +16 more
europepmc   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress. [PDF]

iScience
Sakurai M, Kuwahara T, Suenaga S, Takatori S, Tomita T, Shalit T, Tengstrand E, Hsieh F, Iwatsubo T.   +8 more
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

<i>Trypanosoma evansi</i>: Molecular Characterization and Validation of a Cathepsin-L-like Peptidase as a Potential Therapeutic Target. [PDF]

Pathogens
Bremo A, Pérez YG, Turcios LM, Caffrey CR, Bogyo M, McKerrow JH, Gonzatti M.   +6 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Evaluation of Darifenacin for T-Cell Acute Lymphoblastic Leukemia: Selective Targeting of the Non-Neuronal Cholinergic System and Lysosomal Cathepsins. [PDF]

Int J Mol Sci
Flores-López LA, Martínez-Pérez Y, De la Mora-De la Mora I, López-Herrera G, Gómez-Manzo S, García-Torres I, Hernández-Ochoa B, Enríquez-Flores S.   +7 more
europepmc   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source

Faecal Cathepsin B and S Are Associated With Liver Disease Severity and Adiposity in MASLD. [PDF]

Liver Int
Harberts A, Fondevila MF, Kreimeyer H, Miwa T, Lang S, Demir M, Schnabl B.   +6 more
europepmc   +1 more source