Results 161 to 170 of about 143,203 (306)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Cathepsins and their involvement in immune responses

Swiss Medical Weekly, 2010
Swiss Medical Weekly
doaj   +1 more source

Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage. [PDF]

Res Pract Thromb Haemost
Gi T, Kai K, Shide K, Nakamura E, Oguri N, Aman M, Maekawa K, Moriguchi-Goto S, Nakai M, Shimoda K, Hisada Y, Yamashita A.   +11 more
europepmc   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Relationship between cathepsin K and extracellular matrix dynamics: a comprehensive review. [PDF]

Front Oncol
Zang G, Wang T, Tian H, Wang Y, Jia D, Fan R.   +5 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Targeted near-infrared imaging utilizing a cathepsin-activated fluorophore for the intraoperative detection of canine insulinoma. [PDF]

PLoS One
Griffin MA, Radaelli E, Assenmacher CA, Singhal S, Roses RE, Flesner BK, Stefanovski D, Gill N, Huck JL, Scavello H, Verrelle J, Farrell K, Holt DE.   +12 more
europepmc   +1 more source

Cathepsin B; cathepsin S; IL-4 [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Physicochemical characterization of etch‐and‐rinse adhesive system doped with catechin‐loaded polymeric microparticles

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated the incorporation of epigallocatechin‐3‐gallate (EGCG)‐loaded poly(lactide‐co‐glycolide) (PLGA) microparticles into a two‐step etch‐and‐rinse adhesive and their effects on physicochemical properties and EGCG release. EGCG was added to Single Bond 2 either directly (0.01% and 0.1% w/w) or encapsulated in PLGA 50:50 or 75:25
Jiovanne Rabelo Neri, Nadine Luisa Guimarães Albuquerque, Marcelo Victor Sidou Lemos, Monica Yamauti, Francisco Fábio Oliveira de Sousa, Vanara Florêncio Passos, Sérgio Lima Santiago   +6 more
wiley   +1 more source

The causal relationship between cathepsins and ankylosing spondylitis: a two-sample Mendelian randomization study. [PDF]

Ther Adv Musculoskelet Dis
Wu B, Li R, Li J, An Q, Jin S, Liu Q, Zhang Y, Liu Y.   +7 more
europepmc   +1 more source