Results 241 to 250 of about 106,246 (275)

Largely Distinct Post‐Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.
Anna Stephan, Flavia A. Graca, Suresh Poudel, Yingxue Fu, Yong‐Dong Wang, Myriam Labelle, Fabio Demontis   +6 more
wiley   +1 more source

The Sense of Smell (SoS) Atlas: Its Creation and First Application to Investigate COVID‐19 Related Anosmia With a Comprehensive Quantitative MRI Protocol

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 574-593, February 2026.
ABSTRACT Background The loss of smell (anosmia) has been noted in numerous diseases, including COVID‐19. Inflammatory and microstructural alterations are possible underlying mechanisms of anosmia in COVID‐19. However, no atlas exists to study olfaction and the associated tissue property changes.
Marta Gaviraghi, Eleonora Lupi, Elena Grosso, Andrea Fusari, Mattia Baiguera, Anita Monteverdi, Marco Battiston, Francesco Grussu, Baris Kanber, Ferran Prados Carrasco, Rebecca S. Samson, Janine Makaronidis, Marios C. Yiannakas, Michael S. Zandi, Rachel L. Batterham, Egidio D'Angelo, Fulvia Palesi, Claudia A. M. Gandini Wheeler‐Kingshott   +17 more
wiley   +1 more source

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine MASH Model

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 2, February 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction‐associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non‐invasive biomarkers for tracking disease progression.
Szu‐Jen Wang, Yung‐Ho Wang, Jee‐Fu Huang, En‐Sheng Lin, Wei‐Shiun Chen, Chia‐Yang Li, Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu, Shu‐Chi Wang   +9 more
wiley   +1 more source

Issue Information

Epilepsia Open, Volume 11, Issue 1, Page 1-8, February 2026.
wiley   +1 more source

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New potent cathepsin G phosphonate inhibitors

Bioorganic & Medicinal Chemistry, 2008
Cathepsin G is an enzyme with dual chymotrypsin and trypsin-like specificity. As a leukocyte proteinase it is involved in the early stages of the immune response. In this work the synthesis and inhibitory activity of diaryl phosphonic-type irreversible cathepsin G inhibitors are described.
Marcin, Sieńczyk, Adam, Lesner, Magdalena, Wysocka, Anna, Legowska, Ewa, Pietrusewicz, Krzysztof, Rolka, Józef, Oleksyszyn   +6 more
openaire   +3 more sources

Cathepsin G degrades denatured collagen

Inflammation, 1989
Neutrophils are known to contain several metalloproteinases that can damage collagen, a major structural component of the extracellular matrix. Here a neutrophil serine proteinase secreted from activated neutrophils was shown to cleave denatured collagen (gelatin).
C, Capodici, R A, Berg
openaire   +2 more sources

Specificity of human cathepsin G

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
A series of tetrapeptide p-nitroanilide substrates of the general formula: suc-Ala-Ala-Pro-Aaa-p-nitroanilide was used to map the S1 binding pocket of human cathepsin G. Based on the kcat/Km parameter, the following order of preference was found: Lys=Phe>Arg=Leu>Met>Nle=Nva>Ala>Asp.
J, Polanowska, I, Krokoszynska, H, Czapinska, W, Watorek, M, Dadlez, J, Otlewski   +5 more
openaire   +2 more sources

Renal cathepsin G and angiotensin II generation

Journal of Hypertension, 2006
Alternative pathways of angiotensin II biosynthesis play a significant role in the renin-angiotensin system. In this study porcine renal tissue was investigated for angiotensin II-generating enzymes.Protein extracts from porcine renal tissue were fractionated by liquid chromatography and tested for their angiotensin II-generating activity by the mass ...
Rykl, J., Thiemann, J., Kurzawski, S., Pohl, T., Gobom, J., Zidek, W., Schlüter, H.   +6 more
openaire   +3 more sources

Activation of neutrophil collagenase by cathepsin G

Inflammation, 1989
Collagenase is secreted from neutrophils as a latent or proenzyme. In an effort to understand the mechanism of collagenase activation in inflammation, human peripheral neutrophils (PMNs) were isolated and incubated with the tumor promotor, phorbol myristate acetate (PMA), which induces the neutrophils to degranulate and secrete proteinases.
C, Capodici, G, Muthukumaran, M A, Amoruso, R A, Berg   +3 more
openaire   +2 more sources