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Defensins- and cathepsin G-ANCA in systemic lupus erythematosus
Rheumatology International, 2006In this study, we examined the content of antineutrophil cytoplasmic antibodies (ANCA) against defensins and cathepsin G in sera from systemic lupus erythematosus (SLE) patients and their significance in estimating the activity of SLE. Defensins- and cathepsin G-ANCA in sera from 28 patients with SLE, eight patients with rheumatoid arthritis (RA) and ...
Hiroyuki, Tamiya +8 more
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Digestion of human immunoglobulin G by bovine cathepsin B1
Immunochemistry, 1976Abstract 1. (1) Bovine cathepsin B1 is capable of breaking down human IgG in vitro at pH 4,6, 6.0 and 7.4. 2. (2) Due to high stability of cathepsin B1 at acid pH, prolonged digestion of IgG especially at pH 4.6 was possible and resulted in most extensive breakdown of IgG. 3.
H, Menninger +3 more
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Cathepsin G, a leukocyte protease, activates coagulation factor VIII
Thrombosis and Haemostasis, 2008SummaryNeutrophils and monocytes express cathepsin G and can also bind to activated platelets, thus they can be localized to the site of active coagulation. Previous studies have suggested that cathepsin G inactivated coagulation factorVIII (FVIII) and was thus anticoagulant.
Andrew J, Gale, Diana, Rozenshteyn
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Neutrophil Elastase Potentiates Cathepsin G-lnduced Platelet Activation
Thrombosis and Haemostasis, 1992SummaryWe have previously demonstrated that human neutrophil cathepsin G is a strong platelet agonist that binds to a specific receptor. This work describes the effect of neutrophil elastase on cathepsin G-induced platelet responses. While platelets were not activated by high concentrations of neutrophil elastase by itself, elastase enhanced ...
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Cathepsin G Inactivates Human Protein S in vitro
Pathophysiology of Haemostasis and Thrombosis, 1993Human polymorphonuclear leukocyte cathepsin G was used in vitro to digest human protein S. While clotting assays indicated that the proteinase induced a rapid decrease in activity, polyacrylamide gel electrophoresis-sodium dodecyl sulphate indicated the removal of a peptide of low molecular mass product protein S (des 1-40).
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Role of Cathepsin G in Atherosclerosis
2013Angiotensin II (Ang II) is an important modulator for development of atherosclerosis from early stage foam cell formation to advanced stage plaque rupture. Recently, the importance of locally generated Ang II, especially in macrophages, has become more evident.
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DNA-based aptamers for human cathepsin G
2003The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or
PALUMBO, MANLIO +4 more
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An enzyme immunoassay of human polymorphonuclear leukocyte cathepsin G
Thrombosis Research, 1994An enzyme immunoassay has been developed for the quantitation of human polymorphonuclear leukocyte cathepsin G. The assay had a linear relationship over the range 0.23-4.7 nmol/l (6-125 ug/l) and a detection limit of 0.23 nmol/l (6 ug/l). Recovery in citrated plasma only occurred when the concentration was higher than 4.0 umol/l (110 mg/l). This effect
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Neutrophil cathepsin G increases transendothelial albumin flux.
The Journal of laboratory and clinical medicine, 1989Neutrophils are involved in the development of inflammatory edema in some animal models, but their mechanisms of action are not completely understood. Among injurious agents available for neutrophil-mediated injury are cationic proteins such as cathepsin G.
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