Results 21 to 30 of about 106,246 (275)

Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

Frontiers in Oncology, 2021
AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries, Bridget Chang-McDonald, Josie Patel, Nicholas Bockett, Erin Paterson, Paul F. Davis, Swee T. Tan, Swee T. Tan, Swee T. Tan   +8 more
doaj   +1 more source

Immunotherapy targeting a leader sequence cathepsin G-derived peptide. [PDF]

Leukemia
Myeloid azurophil granules provide a rich source of intracellular leukemia antigens. Cathepsin G (CG) is a serine protease that has higher expression in acute myeloid leukemia (AML) blasts in comparison to normal myeloid progenitors. Based on the unique biology of HLA-A*0201 (HLA-A2), in which presentation of leader sequence (LS)-derived peptides is ...
Shi C, Tian Z, Yan J, Zhang M, Sukhumalchandra P, Chang E, Yang G, You J, Cui M, Shi Q, Kerros C, Philips A, Qiao N, Torikai H, Patchametla S, Sergeeva A, St John L, He H, Wiederschain D, Lee BH, Paulus GLC, Zha D, Molldrem J, Alatrash G.   +23 more
europepmc   +3 more sources

Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]

, 2006
Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ciarán Ó'Fágáin, Collins, Dalton, Deborah M. Ruth, Dowd, Dowd, Fujishima, Gillian McMahon, Haensler, Jakubke, Lozano, Mort, Ménard, Sewald, Stehle, Turk, Zhou   +16 more
core   +1 more source

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase. [PDF]

PLoS ONE, 2015
Giardia duodenalis infections are among the most common causes of waterborne diarrhoeal disease worldwide. At the height of infection, G. duodenalis trophozoites induce multiple pathophysiological processes within intestinal epithelial cells that ...
Amol Bhargava, James A Cotton, Brent R Dixon, Lashitew Gedamu, Robin M Yates, Andre G Buret   +5 more
doaj   +1 more source

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

iScience, 2023
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not well ...
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth   +8 more
doaj   +1 more source

Antigonococcal activity of human neutrophil cathepsin G [PDF]

Infection and Immunity, 1986
We have shown that lysosomal cathepsin G, prepared from acid extracts of granules derived from human polymorphonuclear granulocytes, exhibits potent in vitro antimicrobial activity against Neisseria gonorrhoeae. An isolated isozyme of cathepsin G was found to exhibit antigonococcal activity by a nonenzymatic mechanism in a time-dependent manner ...
W M, Shafer, V C, Onunka, L E, Martin
openaire   +2 more sources

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard, Deluca, Dominga, Höhneke, Clara, Machleidt, Werner, Schaschke, Norbert, Sommerhoff, Christian P.   +5 more
core   +1 more source

Listericidal activity of human neutrophil cathepsin G [PDF]

Journal of General Microbiology, 1990
We demonstrate that cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule.
C E, Alford, E, Amaral, P A, Campbell
openaire   +2 more sources

Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma

Frontiers in Surgery, 2018
AimWe have previously identified and characterized cancer stem cell (CSC) subpopulations in liver metastasis from colon adenocarcinoma (LMCA). In this study we investigated the expression and localization of cathepsins B, D and G, in relation to these ...
Shreeja Mehrotra, Susrutha K. Wickremesekera, Susrutha K. Wickremesekera, Helen D. Brasch, Bede Van Schaijik, Reginald W. Marsh, Reginald W. Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +9 more
doaj   +1 more source

In vitro interaction of hormone-conditioned neutrophils with commensal and uropathogenic Escherichia coli biofilms

Инфекция и иммунитет, 2020
The aim of the work was to examine an interaction between neutrophils conditioned with chorionic gonadotropin, estriol, kisspeptin, leptin, ghrelin and commensal and uropathogenic Escherichia coli biofilms.
I. L. Maslennikova, I. V. Nekrasova, E. G. Orlova, O. L. Gorbunova, S. V. Shirshev   +4 more
doaj   +1 more source