Results 1 to 10 of about 47,172 (255)

Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration [PDF]

Nature Communications
Migrating cells dynamically adapt their morphogenetic programs in response to microenvironmental changes, requiring coordinated spatiotemporal integration of mechanical and biochemical signals.
Vibha Singh, Victor Breton, Christine Viaris de Lesegno, Anne-Sophie Macé, Philippe Bun, Cédric M. Blouin, Amit Singh Vishen, Pierre Sens, Christophe Lamaze   +8 more
doaj   +2 more sources

Caveolae and scaffold detection from single molecule localization microscopy data using deep learning. [PDF]

PLoS ONE, 2019
Caveolae are plasma membrane invaginations whose formation requires caveolin-1 (Cav1), the adaptor protein polymerase I, and the transcript release factor (PTRF or CAVIN1). Caveolae have an important role in cell functioning, signaling, and disease.
Ismail M Khater, Stephane T Aroca-Ouellette, Fanrui Meng, Ivan Robert Nabi, Ghassan Hamarneh   +4 more
doaj   +2 more sources

Ion Channel Regulation in Caveolae and Its Pathological Implications [PDF]

Cells
Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation.
Jianyi Huo, Liangzhu Mo, Xiaojing Lv, Yun Du, Huaqian Yang   +4 more
doaj   +2 more sources

A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain [PDF]

Molecular Therapy: Nucleic Acids
Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to the brain. We have explored a combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection for crossing ...
Betsy Reshma Gilbert, Chirag Miglani, Arundhati Karmakar, Muneesh Pal, Vysakh C. Chandran, Sarika Gupta, Asish Pal, Munia Ganguli   +7 more
doaj   +2 more sources

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway [PDF]

Cell Research, 2008
Hongliang Wang, Chengyu Jiang
exaly   +2 more sources

Caveolae couple mechanical stress to integrin recycling and activation

eLife, 2022
Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane (PM)
Fidel-Nicolás Lolo, Dácil María Pavón, Araceli Grande-García, Alberto Elosegui-Artola, Valeria Inés Segatori, Sara Sánchez, Xavier Trepat, Pere Roca-Cusachs, Miguel A del Pozo   +8 more
doaj   +1 more source

A deep learning-based tool for the automated detection and analysis of caveolae in transmission electron microscopy images

Computational and Structural Biotechnology Journal, 2023
Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron microscopy (TEM) offers the highest resolution for caveolae visualization, but provides complicated images that are ...
María C.M. Aboy-Pardal, Daniel Jimenez-Carretero, Sara Terrés-Domínguez, Dácil M. Pavón, Laura Sotodosos-Alonso, Víctor Jiménez-Jiménez, Fátima Sánchez-Cabo, Miguel A. Del Pozo   +7 more
doaj   +1 more source

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Cells, 2023
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction
Laura Sotodosos-Alonso, Marta Pulgarín-Alfaro, Miguel A. del Pozo   +2 more
doaj   +1 more source

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Nature Communications, 2022
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García, Sara Sánchez-Perales, Patricia Jarabo, Enrique Calvo, Trevor Huyton, Liran Fu, Sheung Chun Ng, Laura Sotodosos-Alonso, Jesús Vázquez, Sergio Casas-Tintó, Dirk Görlich, Asier Echarri, Miguel A. Del Pozo   +12 more
doaj   +1 more source

APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling. [PDF]

Nat Commun
Kim JD, Chaudhary S, Chen W, Astin J, Crosier PS, Yu P, Cooke JP, Pownall HJ, Bellen HJ, Le NT, Kiss DL, Wang G, Rockson SG, Chen H, Fang L.   +14 more
europepmc   +3 more sources