Results 71 to 80 of about 13,385 (166)

Selective Absence of Co‐Inhibitory Receptor‐Expressing CD4+ T Cells in Lungs of Obese House Dust Mite‐Allergic C57BL/6 Mice

Allergy, EarlyView.
Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe, Daniel P. Potaczek, Kim Pauck, Andrea Berlin, Bilal Alashkar Alhamwe, Stefanie Hagner, Andrea Nist, Elke Pogge von Strandmann, Thorsten Stiewe, Paul Klemm, Hartmann Raifer, Clemens Thölken, Holger Garn   +12 more
wiley   +1 more source

CCL11–CCR3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation

, 2011
CCR3 is a specific marker of anaplastic large cell lymphoma (ALCL) cells. ALCL cells also express CCL11, a ligand for CCR3, leading to the hypothesis that CCL11 may play an autocrine role in ALCL progression.
Yayoi Tada, Hitoshi Okochi, Shinichi Sato, Makoto Sugaya, Takafumi Kadono, Takashi Murakami, Kunihiko Tamaki, Tomomitsu Miyagaki, Yoshihide Asano   +8 more
core   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control

Frontiers in Immunology, 2018
Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIV-ECs) with a suppressed viremia.
Mónica Gutiérrez-Rivas, María Ángeles Jiménez-Sousa, Norma Rallón, Norma Rallón, José Luis Jiménez, José Luis Jiménez, Clara Restrepo, Clara Restrepo, Agathe León, Marta Montero-Alonso, Juan González-García, María Ángeles Muñoz-Fernández, María Ángeles Muñoz-Fernández, José Miguel Benito, José Miguel Benito, Salvador Resino, on Behalf of ECRIS Integrated in the Spanish AIDS Research Network   +16 more
doaj   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11

, 2011
Recent genome-wide association studies of pediatric inflammatory bowel disease have implicated the 17q12 loci, which contains the eosinophil-specific chemokine gene CCL11, with early-onset inflammatory bowel disease susceptibility.
Simon P. Hogan, Kris Steinbrecher, Amanda Waddell, Burke Donovan, Ariel Munitz, Richard Ahrens, Marc E. Rothenberg   +6 more
core   +1 more source

Overexpression of microRNA-155 suppresses chemokine expression induced by Interleukin-13 in BEAS-2B human bronchial epithelial cells

Allergology International, 2016
Background: MicroRNAs are non-coding small RNAs that regulate expression of target genes by binding to 3′ untranslated regions. In this study, we used bronchial epithelial cells to investigate in vitro the role of the microRNA miR-155 in the expression ...
Satoshi Matsukura, Yuki Osakabe, Ayaka Sekiguchi, Daisuke Inoue, Yusuke Kakiuchi, Toshitaka Funaki, Yohei Yamazaki, Hiromi Takayasu, Hidetsugu Tateno, Eisuke Kato, Aya Wakabayashi, Makoto Hayashi, Gen Ishii, Fumihiro Yamaguchi, Yutaka Tsuchiya, Keita Kasahara, Hironori Sagara, Fumio Kokubu   +17 more
doaj   +1 more source

Involvement of Eotaxins (CCL11, CCL24, CCL26) in Pathogenesis of Osteopenia and Osteoporosis

Iranian Journal of Public Health, 2020
Background: The purpose of this study was to investigate the role of eotaxin family members including C-C motif chemokine 11 (CCL11), C-C motif chemokine 24 (CCL24), and C-C motif chemokine 26 (CCL26) as the subgroups of CC-chemokine in patients affected
Hadis AHMADI, Hossein KHORRAMDELAZAD, Gholamhossein HASSANSHAHI, Mitra ABBASI FARD, Zahra AHMADI, Mojgan NOROOZI KARIMABAD, Majid MOLLAHOSSEINI   +6 more
doaj   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source