Results 11 to 20 of about 76,869 (253)

CCL5 regulation of mucosal chlamydial immunity and infection [PDF]

BMC Microbiology, 2008
Background Following genital chlamydial infection, an early T helper type 1 (Th1)-associated immune response precedes the activation and recruitment of specific Th1 cells bearing distinct chemokine receptors, subsequently leading to the clearance of ...
Igietseme Joseph U, Taub Dennis D, Singh Shailesh, Singh Udai P, Sakthivel Senthilkumar K, Lillard James W   +5 more
doaj   +3 more sources

The CCL5/CCR5 Axis in Cancer Progression [PDF]

Cancers, 2020
Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5 and its receptor CCR5 have been found in hematological malignancies and solid tumors. Numerous preclinical in
Donatella Aldinucci, Cinzia Borghese, Naike Casagrande   +2 more
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Targeting CCL5 in inflammation [PDF]

Expert Opinion on Therapeutic Targets, 2013
Chemokines play important roles in inflammation and in immune responses. This article will discuss the current literature on the C-C chemokine ligand 5 (CCL5), and whether it is a therapeutic target in the context of various allergic, autoimmune or infectious diseases.Small-molecule inhibitors, chemokine and chemokine receptor-deficient mice ...
Marques, Rafael Elias, Guabiraba, Rodrigo, Russo, Remo Castro, Teixeira, Mauro Martins   +3 more
openaire   +4 more sources

CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation. [PDF]

The Journal of biological chemistry, 2006
CCL5 (RANTES (regulated on activation normal T cell expressed and secreted)) and its cognate receptor, CCR5, have been implicated in T cell activation. CCL5 binding to glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5, thereby immobilizing CCL5 to provide the directional signal. In two CCR5-expressing human T cell
Thomas T, Murooka, Mark M, Wong, Ramtin, Rahbar, Beata, Majchrzak-Kita, Amanda E I, Proudfoot, Eleanor N, Fish   +5 more
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CCL5 Modulates Pneumococcal Immunity and Carriage [PDF]

The Journal of Immunology, 2006
AbstractUnderstanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases.
Ravichandran, Palaniappan, Shailesh, Singh, Udai P, Singh, Rajesh, Singh, Edwin W, Ades, David E, Briles, Susan K, Hollingshead, Walter, Royal, Jacquelyn S, Sampson, Jonathan K, Stiles, Dennis D, Taub, James W, Lillard   +11 more
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Targeting CCL5 signaling attenuates neuroinflammation after seizure

CNS Neuroscience & Therapeutics, 2022
AbstractBackgroundEpilepsy is a neurological condition that causes unprovoked, recurrent seizures. Accumulating evidence from clinical and experimental studies indicates that neuroinflammation exacerbates seizure activity.MethodsWe investigated the transcriptional changes occurring in specific brain domains of a seizure mouse model, using 10× Genomics ...
Zhuoran Zhang, Yan Li, Shihe Jiang, Fu‐Dong Shi, Kaibin Shi, Wei‐Na Jin   +5 more
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The Inflammatory Chemokine CCL5 and Cancer Progression [PDF]

Mediators of Inflammation, 2014
Until recently, inflammatory chemokines were viewed mainly as indispensable “gate keepers” of immunity and inflammation. However, updated research indicates that cancer cells subvert the normal chemokine system and these molecules and their receptors become important constituents of the tumor microenvironment with very different ways to exert tumor ...
Donatella Aldinucci, Alfonso Colombatti
openaire   +4 more sources

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
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Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells

Frontiers in Immunology, 2018
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D’Amico, Silvano Sozzani, Tiziana Musso   +11 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
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