Results 31 to 40 of about 76,869 (253)

Role of CCL5 (RANTES) in Viral Lung Disease [PDF]

Journal of Virology, 2006
ABSTRACTCCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics. To examine the role of CCL5 in viral lung disease, we measured its production during primary respiratory syncytial virus (RSV) infection and during secondary infection after sensitizing vaccination that
Culley, Fiona J., Pennycook, Alasdair M J, Tregoning, John S., Dodd, Jonathan S., Walzl, Gerhard, Wells, Timothy N., Hussell, Tracy, Openshaw, Peter J M   +7 more
openaire   +2 more sources

Regulation of CCL5 expression in smooth muscle cells following arterial injury. [PDF]

PLoS ONE, 2012
Chemokines play a crucial role in inflammation and in the pathophysiology of atherosclerosis by recruiting inflammatory immune cells to the endothelium. Chemokine CCL5 has been shown to be involved in atherosclerosis progression. However, little is known
Huan Liu, Huan Ning, Hongchao Men, Rong Hou, Mingui Fu, Hailin Zhang, Jianguo Liu   +6 more
doaj   +1 more source

The regulatory network of the chemokine CCL5 in colorectal cancer

Annals of Medicine, 2023
The chemokine CCL5 plays a potential role in the occurrence and development of colorectal cancer (CRC). Previous studies have shown that CCL5 directly acts on tumor cells to change tumor metastatic rates.
Xin-Feng Zhang, Xiao-Li Zhang, Ya-Jing Wang, Yuan Fang, Meng-Li Li, Xing-Yu Liu, Hua-You Luo, Yan Tian   +7 more
doaj   +1 more source

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

CCL5’s Role in Periodontal Disease: A Narrative Review

International Journal of Molecular Sciences, 2023
Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C-C motif chemokine ligand 5), also known as RANTES (regulated on activation, normal T cell expressed ...
Katarzyna Barczak, Agnieszka Droździk, Mateusz Bosiacki, Ryta Łagocka, Diana Cenariu, Willi Andrei Uriciuc, Irena Baranowska-Bosiacka   +6 more
openaire   +2 more sources

Tumor Extracellular Vesicles Regulate Macrophage-Driven Metastasis through CCL5 [PDF]

Cancers, 2021
Purpose: To understand how tumor cells alter macrophage biology once they are recruited to triple-negative breast cancer (TNBC) tumors by CCL5. Method: Mouse bone marrow derived macrophage (BMDMs) were isolated and treated with recombinant CCL5 protein alone, with tumor cell conditioned media, or with tumor extracellular vesicles (EVs).
Daniel C. Rabe, Nykia D. Walker, Felicia D. Rustandy, Jessica Wallace, Jiyoung Lee, Shannon L. Stott, Marsha Rich Rosner   +6 more
openaire   +2 more sources

A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. [PDF]

PLoS ONE, 2016
The role of CC chemokine receptor 5 (CCR5) and its ligand CCL5 on the pathogenesis of HIV infection has been well studied but not for HCV infection. Here, we investigated whether CCL5 haplotypes influence HIV and HCV seropositivity among 373 Caucasian ...
Kristi Huik, Radko Avi, Merit Pauskar, Eveli Kallas, Ene-Ly Jõgeda, Tõnis Karki, Kristi Rüütel, Ave Talu, Katri Abel-Ollo, Anneli Uusküla, Andrew Carrillo, Sunil K Ahuja, Weijing He, Irja Lutsar   +13 more
doaj   +1 more source

CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury

Redox Biology, 2021
Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI induces secondary effects which damage neurons ...
Man-Hau Ho, Chia-Hung Yen, Tsung-Hsun Hsieh, Tzu-Jen Kao, Jing-Yuan Chiu, Yung-Hsiao Chiang, Barry J. Hoffer, Wen-Chang Chang, Szu-Yi Chou   +8 more
doaj   +1 more source

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. [PDF]

, 2016
CC chemokine ligand 5 (CCL5) and CCL3 are critical for immune surveillance and inflammation. Consequently, they are linked to the pathogenesis of many inflammatory conditions and are therapeutic targets.
Banerjee, S, Dinner, AR, Huang, TY, Hung, SC, Liang, WG, Tang, WJ, Triandafillou, CG, Zulueta, MM   +7 more
core   +1 more source

Network Pharmacology and Inflammatory Microenvironment Strategy Approach to Finding the Potential Target of Siraitia grosvenorii (Luo Han Guo) for Glioblastoma

Frontiers in Genetics, 2021
Background: Glioblastoma (GBM) is the most common and aggressive primary intracranial tumor of the central nervous system, and the prognosis of GBM remains a challenge using the standard methods of treatment—TMZ, radiation, and surgical resection ...
Juan Li, De Bi, Xin Zhang, Yunpeng Cao, Kun Lv, Kun Lv, Lan Jiang, Lan Jiang   +7 more
doaj   +1 more source