Results 1 to 10 of about 65,957 (231)

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds? [PDF]

Frontiers in Immunology, 2021
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Liyang Fei, Xiaochen Ren, Haijia Yu, Yifan Zhan   +3 more
doaj   +2 more sources

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis [PDF]

Journal of Neuroinflammation
Central nervous system (CNS) resident memory CD8 T cells (TRM) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment.
Shenjian Ai, Artem Arutyunov, Joshua Liu, Jeremy D. Hill, Xiaoping Jiang, Robyn S. Klein   +5 more
doaj   +2 more sources

Association of CCL2/CCR2 gene polymorphisms and bladder cancer risk in a hispanic-rich US population. [PDF]

Bladder Cancer
Harmon JF, Santos E, Johnson-Pais TL, Leach RJ, Gelfond J, Mukherjee N, Svatek RS.   +6 more
europepmc   +2 more sources

Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment [PDF]

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) is the most intractable cancer, demonstrating abundant stroma in the tumor microenvironment (TME). Previously, we reported that CXC chemokines contributed to the progression of PDAC through tumor-stromal ...
Gen Kimura, Hideaki Ijichi, Makoto Sano, Genso Notoya, Koji Miyabayashi, Ryota Takahashi, Takahiro Kishikawa, Mitsuhiro Fujishiro   +7 more
doaj   +2 more sources

CCR2 Antagonist CCX872-B [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Role of CCR2 in orthodontic tooth movement

American Journal of Orthodontics and Dentofacial Orthopedics, 2012
Cytokines and chemokines regulate bone remodeling during orthodontic tooth movement. CC chemokine ligand 2 (CCL2) is involved in osteoclast recruitment and activity, and its expression is increased in periodontal tissues under mechanical loading. In this study, we investigated whether the CC chemokine receptor 2 (CCR2)-CCL2 axis influences orthodontic ...
Silvana Rodrigues de Albuquerque Taddei, Ildeu Andrade, Celso Martins Queiroz‐Junior, Thiago Pompermaier Garlet, Gustavo Pompermaier Garlet, Fernando Q. Cunha, Mauro Martins Teixeira, Tarcı́lia Aparecida Silva   +7 more
openalex   +3 more sources

Hydrogen relieves neuropathic pain in diabetic rats by inhibiting mcp1 and ccr2 expressions [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
We aimed to explore the mechanism for hydrogen in the treatment of neuropathic pain in diabetic rats. Eight-week-old male SD rats were randomly divided into control, model and hydrogen treatment groups.
Pin WANG, Lanying YOU, Qian LI, Hao WANG, Yun LONG, Wei CHEN   +5 more
doaj   +1 more source

GLUT1 Mediates the Metabolic Reprogramming and Inflammation of CCR2$^+$ Monocytes/Macrophages from Patients with DCM

Frontiers in Bioscience-Landmark, 2023
Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng, Hantao Jiang, Xueyuan Yang, Hongliang Cong, Lan Li, Jinping Feng   +5 more
doaj   +1 more source

An Alternative Perspective to the FMF Clinic: MCP-1 (A-2518G) and CCR2 (G190A) Polymorphisms and MCP1 Expression

Journal of Contemporary Medicine, 2022
Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process.
Nadir Koçak, Şenol Çitli
doaj   +1 more source

Silencing of CCR2 in myocarditis [PDF]

European Heart Journal, 2014
Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes. We investigated whether in vivo administration of nanoparticle-encapsulated siRNA targeting chemokine (C-C motif) receptor 2 (CCR2)-a chemokine receptor ...
Leuschner, Florian, Courties, Gabriel, Dutta, Partha, Mortensen, Luke, Gorbatov, Rostic, Sena, Brena, Novobrantseva, Tatiana, Borodovsky, Anna, Fitzgerald, Kevin, Koteliansky, Victor, Iwamoto, Yoshiko, Bohlender, Marina, Meyer, Soeren, Lasitschka, Felix, Meder, Benjamin, Katus, Hugo, Lin, Charles, Libby, Peter, Swirski, Filip, Anderson, Daniel, Weissleder, Ralph, Nahrendorf, Matthias   +21 more
openaire   +3 more sources