Results 1 to 10 of about 71,715 (302)

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Frontiers in Immunology, 2021
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory functions, prompting the development of CCR2 antagonists to dampen unwanted immune responses in inflammatory and autoimmune diseases.
Liyang Fei, Xiaochen Ren, Haijia Yu, Yifan Zhan   +3 more
doaj   +2 more sources

CCL2/CCR2 signaling in cancer pathogenesis [PDF]

Cell Communication and Signaling, 2020
Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Q. Hao, J. Vadgama, Piwen Wang
semanticscholar   +4 more sources

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury [PDF]

Circulation Research, 2019
Rationale: Recent advancements have brought to light the origins, complexity, and functions of tissue-resident macrophages. However, in the context of tissue injury or disease, large numbers of monocytes infiltrate the heart and are thought to contribute
G. Bajpai, Andrea L. Bredemeyer, Wenjun Li, Konstantin Zaitsev, Andrew L. Koenig, Inessa Lokshina, Jayaram Mohan, Brooke Ivey, His-Min Hsiao, C. Weinheimer, A. Kovács, S. Epelman, M. Artyomov, D. Kreisel, Kory J. Lavine   +14 more
semanticscholar   +3 more sources

Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway

Journal of Neuroinflammation, 2022
Background Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients with subarachnoid hemorrhage (SAH). We investigated the role of C–C motif chemokine receptor 2 (CCR2) in SAH.
Qi Tian, Yujia Guo, Shi Feng, Chengli Liu, Peibang He, Jianfeng Wang, Wenrui Han, Chen Yang, Zhan Zhang, Mingchang Li   +9 more
doaj   +2 more sources

The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

Arthritis Research & Therapy, 2021
Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM).
Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller   +6 more
doaj   +2 more sources

CCR2 Signaling Restricts SARS-CoV-2 Infection

mBio, 2021
SARS-CoV-2 has caused a historic pandemic of respiratory disease (COVID-19), and current evidence suggests that severe disease is associated with dysregulated immunity within the respiratory tract.
Abigail Vanderheiden, Jeronay Thomas, A. Soung, Meredith E. Davis-Gardner, K. Floyd, Fengzhi Jin, David A. Cowan, K. Pellegrini, A. Creanga, A. Pegu, Alexandrine Derrien-Colemyn, P. Shi, A. Grakoui, R. Klein, S. Bosinger, J. Kohlmeier, Vineet D. Menachery, M. Suthar   +17 more
semanticscholar   +5 more sources

Modulation of CCR2/CCL2 molecular axis in the expansion and rupture of abdominal aortic aneurysms [PDF]

Frontiers in Cardiovascular Medicine
The CCR2/CCL2 molecular axis is a critical mediator of abdominal aortic aneurysm (AAA) pathogenesis. It has been demonstrated to drive chronic inflammation, extracellular matrix degradation, and vascular remodeling through the recruitment and activation ...
Ryan Wahidi, Ryan Wahidi, Santiago Elizondo-Benedetto, Ryan Catlett, Bera Koklu, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed, Mohamed A. Zayed   +11 more
doaj   +2 more sources

Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment [PDF]

Scientific Reports
Pancreatic ductal adenocarcinoma (PDAC) is the most intractable cancer, demonstrating abundant stroma in the tumor microenvironment (TME). Previously, we reported that CXC chemokines contributed to the progression of PDAC through tumor-stromal ...
Gen Kimura, Hideaki Ijichi, Makoto Sano, Genso Notoya, Koji Miyabayashi, Ryota Takahashi, Takahiro Kishikawa, Mitsuhiro Fujishiro   +7 more
doaj   +2 more sources

Hydrogen relieves neuropathic pain in diabetic rats by inhibiting mcp1 and ccr2 expressions [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
We aimed to explore the mechanism for hydrogen in the treatment of neuropathic pain in diabetic rats. Eight-week-old male SD rats were randomly divided into control, model and hydrogen treatment groups.
Pin WANG, Lanying YOU, Qian LI, Hao WANG, Yun LONG, Wei CHEN   +5 more
doaj   +1 more source

M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair

Advancement of science, 2023
Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing macrophages have phenotypical similarities to M1‐polarized macrophages, are pro ...
Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan   +11 more
semanticscholar   +1 more source