Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members [PDF]
eLife, 2019 HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil +12 more
doaj +3 more sources
IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. [PDF]
PLoS ONE, 2013 Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis.
Shannon K Bromley +3 more
doaj +5 more sources
Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
core +12 more sources
Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
Cell Proliferation, 2021 The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms.
Maosen Xu +4 more
semanticscholar +1 more source
Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
Frontiers in Immunology, 2022 The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease.
Haixia Zhang +10 more
semanticscholar +1 more source
CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus
Science Advances, 2023 Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus causing a high fatality rate of up to 30%. To date, the receptor mediating SFTSV entry remained uncharacterized, hindering the understanding of disease ...
Lei-ke Zhang +13 more
semanticscholar +1 more source
Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease
Frontiers in Immunology, 2022 Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system.
Shaoping She +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs +7 more
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Macrophages expressing CC chemokine receptor 2 (CCR2) possess characteristics and performance akin to M1 polarized macrophages, which promote inflammation.
Chao Feng +5 more
doaj +1 more source
Journal of Contemporary Medicine, 2022 Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process.
Nadir Koçak, Şenol Çitli
doaj +1 more source