Results 11 to 20 of about 65,957 (231)
Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members [PDF]
eLife, 2019 HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction ...
Elena Gonzalo-Gil +12 more
doaj +3 more sources
IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. [PDF]
PLoS ONE, 2013 Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis.
Shannon K Bromley +3 more
doaj +5 more sources
Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
core +12 more sources
CCL2/CCR2 signaling in cancer pathogenesis [PDF]
Cell Communication and Signaling, 2020 AbstractChemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer.
Qiongyu Hao +2 more
openaire +3 more sources
CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015 The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy +2 more
openaire +4 more sources
CCR2 promotes hepatic fibrosis in mice # [PDF]
Hepatology, 2009 Abstract Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, and MCP-3, in hepatic ...
Seki, E. +7 more
openaire +4 more sources
Biomolecules, 2023 In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology.
Helen Willcockson +9 more
doaj +1 more source
Ccr2 suppression by minocycline in Cx3cr1/Ccr2-visualized inherited retinal degeneration [PDF]
, 2020 AbstractRetinal inflammation accelerates photoreceptor cell death (PCD) caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has previously been reported to show PCD rescue effect in retinal degeneration.
Ryo Terauchi +5 more
openaire +1 more source
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Scientific Reports, 2021 Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients.
Wataru Shiraishi +7 more
doaj +1 more source