Results 21 to 30 of about 71,715 (302)

Role of MCP-1/CCR2 axis in renal fibrosis: Mechanisms and therapeutic targeting

Medicine, 2023
Renal fibrosis is a common pathological manifestation in various chronic kidney diseases. Inflammation plays a central role in renal fibrosis development.
Shiyang He, Lan Yao, Jun Li
semanticscholar   +1 more source

Silencing of CCR2 in myocarditis [PDF]

European Heart Journal, 2014
Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes. We investigated whether in vivo administration of nanoparticle-encapsulated siRNA targeting chemokine (C-C motif) receptor 2 (CCR2)-a chemokine receptor ...
Leuschner, Florian, Courties, Gabriel, Dutta, Partha, Mortensen, Luke, Gorbatov, Rostic, Sena, Brena, Novobrantseva, Tatiana, Borodovsky, Anna, Fitzgerald, Kevin, Koteliansky, Victor, Iwamoto, Yoshiko, Bohlender, Marina, Meyer, Soeren, Lasitschka, Felix, Meder, Benjamin, Katus, Hugo, Lin, Charles, Libby, Peter, Swirski, Filip, Anderson, Daniel, Weissleder, Ralph, Nahrendorf, Matthias   +21 more
openaire   +3 more sources

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Molecular Cancer, 2020
The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis ...
Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, W. Cui, X. Jia   +9 more
semanticscholar   +1 more source

The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms

Science Signaling, 2023
C-C chemokine receptor 2 (CCR2) is a dual-function receptor. Similar to other G protein–coupled chemokine receptors, it promotes monocyte infiltration into tissues in response to the chemokine CCL2, and, like atypical chemokine receptors (ACKRs), it ...
Thomas Shroka, I. Kufareva, Catherina L. Salanga, T. Handel   +3 more
semanticscholar   +1 more source

Peripheral CCL2-CCR2 signalling contributes to chronic headache-related sensitization.

Brain : a journal of neurology, 2023
Migraine, especially chronic migraine, is highly debilitating and still lacks effective treatment. The persistent headache arises from activation and sensitization of primary afferent neurons in the trigeminovascular pathway, but the underlying ...
S. Ryu, Xuemei Liu, Tingting Guo, Zhaohua Guo, Jintao Zhang, Y. Cao   +5 more
semanticscholar   +1 more source

CCL2-CCR2 Signaling in Disease Pathogenesis [PDF]

Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular ...
O'Connor, Tracy, Borsig, Lubor, Heikenwalder, Mathias   +2 more
openaire   +4 more sources

CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice

Diabetologia, 2023
Aims/hypothesis Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy.
A. Saadane, A. Veenstra, Martin S Minns, Jie-long Tang, Yunpeng Du, Fatima Abubakr Elghazali, E. Lessieur, E. Pearlman, T. Kern   +8 more
semanticscholar   +1 more source

CCR2 promotes hepatic fibrosis in mice # [PDF]

Hepatology, 2009
Abstract Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of CCR2, the receptor for monocyte chemoattractant protein (MCP)-1, MCP-2, and MCP-3, in hepatic ...
Seki, E., De Minicis, S., Inokuchi, S., Taura, K., Miyai, K., van Rooijen, N., Schwabe, R.F., Brenner, D.A.   +7 more
openaire   +4 more sources

CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis

Biomolecules, 2023
In osteoarthritis (OA), bone changes are radiological hallmarks and are considered important for disease progression. The C-C chemokine receptor-2 (CCR2) has been shown to play an important role in bone physiology.
Helen Willcockson, Huseyin Ozkan, José Valdés-Fernández, Liubov Arbeeva, Esra Mucahit, Layla Musawwir, Lola B. Hooper, Froilán Granero-Moltó, Felipe Prósper, Lara Longobardi   +9 more
doaj   +1 more source

The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials

International Journal of Molecular Sciences, 2022
C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation.
Huixia Geng, Luna Chen, Jing Tang, Yi'ang Chen, Lai Wang   +4 more
semanticscholar   +1 more source