Results 31 to 40 of about 71,715 (302)
Ccr2 suppression by minocycline in Cx3cr1/Ccr2-visualized inherited retinal degeneration [PDF]
, 2020 AbstractRetinal inflammation accelerates photoreceptor cell death (PCD) caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has previously been reported to show PCD rescue effect in retinal degeneration.
Ryo Terauchi +5 more
openaire +1 more source
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Roles of CCL2-CCR2 Axis in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is
S. Kadomoto, K. Izumi, A. Mizokami
semanticscholar +1 more source
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]
, 2015 Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay +6 more
core +5 more sources
Scientific Reports, 2021 Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients.
Wataru Shiraishi +7 more
doaj +1 more source
Targeting the CCL2–CCR2 axis for atheroprotection
European Heart Journal, 2022 AbstractDecades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for lowering residual vascular risk.
Marios K Georgakis +4 more
openaire +4 more sources
Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. [PDF]
, 2018 Traumatic brain injury (TBI) is a leading cause for neurological disabilities world-wide. TBI occurs most frequently among the elderly population, and elderly TBI survivors suffer from reduced recovery and poorer quality of life. The effect of age on the
Chou, Austin +4 more
core +3 more sources
Cancer immunology research, 2021 A role of B7-H3 in M2 macrophage–mediated immunosuppression in ovarian cancer is demonstrated. The data reveal B7-H3′s potential as a therapeutic target to enhance antitumor responses in ovarian cancer, highlighting a differential role from other B7 ...
T. Miyamoto +16 more
semanticscholar +1 more source
Possible association between expression of chemokine receptor-2 (CCR2) and amyotrophic lateral sclerosis (ALS) patients of North India. [PDF]
PLoS ONE, 2012 BACKGROUND AND OBJECTIVES: We earlier reported elevated chemokine ligand-2 (CCL2) in Indian amyotrophic lateral sclerosis (ALS) patients. We now analysed chemokine receptor-2 (CCR2), the receptor of CCL2, in these ALS patients.
Pawan K Gupta +3 more
doaj +1 more source
Immuno, 2021 Although exercise-induced humoral factors known as exerkines benefit systemic health, the role of most exerkines has not been investigated. Monocyte chemoattractant protein-1 (MCP-1) is a representative chemokine whose circulating concentrations increase
Takaki Tominaga +2 more
doaj +1 more source