Results 41 to 50 of about 71,715 (302)

Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2

Journal of Experimental Medicine, 2022
Changes in monocyte state occur during inflammation. We show that following glomerular inflammation, CCR2+CX3CR1+ double-positive monocytes, which are preferentially recruited, acquire macrophage features while still within the renal vasculature, in a ...
V. Mysore, S. Tahir, K. Furuhashi, Jatin Arora, F. Rosetti, X. Cullere, Pascal Yazbeck, Miroslav Sekulic, M. Lemieux, S. Raychaudhuri, B. Horwitz, T. Mayadas   +11 more
semanticscholar   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Luckow, Bruno, Mack, Matthias, Schlöndorff, Detlef, Vielhauer, Volker   +5 more
core   +1 more source

Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression

OncoImmunology, 2020
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that promote tumor progression by inhibiting anti-tumor immunity and may be the cause of patient resistance to immune checkpoint inhibitors (ICIs).
Zhiqi Xie, Tamami Ikegami, Yukio Ago, Naoki Okada, Masashi Tachibana   +4 more
doaj   +1 more source

Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice. [PDF]

PLoS ONE, 2016
CCR2 is a chemokine receptor expressed on the surface of blood leukocytes, particularly «Ly6Chi» inflammatory monocytes and microglia. Signaling through this receptor is thought to influence the immune activity of microglia as well as monocytes egress ...
Rafik Menasria, Coraline Canivet, Jocelyne Piret, Jean Gosselin, Guy Boivin   +4 more
doaj   +1 more source

The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

Journal of Cellular Physiology, 2021
Monocyte chemoattractant protein‐1, also called chemokine (C‐C motif) ligand 2 (CCL2) or small inducible cytokine A2, is an inflammatory mediator capable of recruiting monocytes, memory T cells, and dendritic cells.
Sipin Zhu, Mei Liu, Samuel Bennett, Ziyi Wang, K. Pfleger, Jiake Xu   +5 more
semanticscholar   +1 more source

CCR2− and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion [PDF]

Mucosal Immunology, 2017
Macrophages are distributed throughout the body and are crucial for the restoration of damaged tissues. However, their characteristics in the cornea and roles in the repair of corneal injures are unclear. Here we show that corneal macrophages can be classified as CCR2- macrophages, which already exist in the cornea at embryonic day 12.5 (E12.5) and are
Liu, J, Xue, Y, Dong, D, Xiao, C, Lin, C, Wang, H, Song, F, Fu, T, Wang, Z, Chen, J, Pan, H, Li, Y, Cai, D, Li, Z   +13 more
openaire   +2 more sources

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source

Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model

Journal of Pain Research, 2022
Megumi Sumizono,1,2 Yushin Yoshizato,1 Ryohei Yamamoto,1 Takaki Imai,1 Akira Tani,2 Kazuki Nakanishi,2 Tomomi Nakakogawa,2 Teruki Matsuoka,2 Ryoma Matsuzaki,2 Takashi Tanaka,3 Harutoshi Sakakima2 1Department of Rehabilitation, Kyushu University of ...
Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H   +10 more
doaj  

CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma

Journal of Experimental Medicine, 2022
This preclinical study showed that CCR2/CCR5 dual-antagonist counteracts radiation-induced suppressive signals in myeloid cells and upregulates the effector T cell pathway and supported the ongoing clinical trial of the combination therapy of radiation ...
Jianxin Wang, May Tun Saung, Keyu Li, Juan Fu, K. Fujiwara, N. Niu, S. Muth, Junke Wang, Yao Xu, N. Rozich, H. Zlomke, Sophia Y. Chen, Birginia Espinoza, Mackenzie Henderson, Vanessa Funes, B. Herbst, D. Ding, Christina Twyman-Saint Victor, Qihong Zhao, A. Narang, Jin He, Lei Zheng   +21 more
semanticscholar   +1 more source

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources