Results 71 to 80 of about 71,715 (302)

AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages. [PDF]

PLoS ONE, 2016
C-C chemokine receptor 2 (Ccr2) is a key pro-inflammatory marker of classic (M1) macrophage activation. Although Ccr2 is known to be expressed both constitutively and inductively, the full regulatory mechanism of its expression remains unclear.
Fumiaki Kumase, Kimio Takeuchi, Yuki Morizane, Jun Suzuki, Hidetaka Matsumoto, Keiko Kataoka, Ahmad Al-Moujahed, Daniel E Maidana, Joan W Miller, Demetrios G Vavvas   +9 more
doaj   +1 more source

The CCR2⁺ Monocyte Subsets Increase in Obese Boys but Not Girls with Abnormally High Carotid Intima-Media Thickness: A Pilot Study

Journal of Cardiovascular Development and Disease, 2022
The differential contribution of monocyte subsets expressing the C-C chemokine receptor 2 (CCR2) to subclinical atherosclerosis in girls and boys is unclear.
María José Garcés-Hernández, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernández-Ruiz, Jessica Lakshmi Prieto-Chávez, Lourdes Andrea Arriaga-Pizano, Eréndira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos López-Alvarenga, José Luis Pérez-Hernández, Gloria Queipo-García   +11 more
doaj   +1 more source

Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy

Communications Biology, 2020
Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical management of multiple cancer types, however, many tumors still fail to respond.
M. Tu, Hany A. Abdel-Hafiz, Robert T. Jones, A. Jean, K. Hoff, Jason E. Duex, Ana Chauca-Diaz, J. Costello, Garrett M. Dancik, B. Tamburini, B. Czerniak, J. Kaye, D. Theodorescu   +12 more
semanticscholar   +1 more source

CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor

Scientific Reports, 2022
Macrophages are a heterogeneous population of mononuclear phagocytes abundantly distributed throughout the intestinal compartments that adapt to microenvironmental specific cues.
Shorouk El Sayed, Izabel Patik, Naresh S. Redhu, J. Glickman, K. Karagiannis, El Sayed Y. El Naenaeey, G. Elmowalid, Ashraf M. Abd El Wahab, S. Snapper, B. Horwitz   +9 more
semanticscholar   +1 more source

Сhanges of the functional phenotype of circulating monocytes during pregnancy

Медицинская иммунология
Rearrangement of the immune system during pregnancy is a strictly controlled, dynamic process in which the first and third trimesters are, respectively, pro-inflammatory, and anti-inflammatory periods.
N. G. Bukhtueva, O. Yu. Leplina, E. Ya. Shevela, M. A. Tikhonova, N. M. Pasman, A. A. Ostanin, E. R. Chernykh   +6 more
doaj   +1 more source

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

Science Advances, 2021
Astrocyte-secreted CCL2 promotes cancer cell extravasation at the brain via chemotaxis and chemokinesis. Although brain metastases are common in cancer patients, little is known about the mechanisms of cancer extravasation across the blood-brain barrier (
Cynthia Hajal, Yoojin Shin, Leanne Li, J. C. Serrano, T. Jacks, R. Kamm   +5 more
semanticscholar   +1 more source

Tumor-infiltrating CCR2+ inflammatory monocytes counteract specific immunotherapy

Frontiers in Immunology, 2023
Tumor development and progression is shaped by the tumor microenvironment (TME), a heterogeneous assembly of infiltrating and resident host cells, their secreted mediators and intercellular matrix. In this context, tumors are infiltrated by various immune cells with either pro-tumoral or anti-tumoral functions.
Bartneck, Joschka, Hartmann, Ann-Kathrin, Stein, Lara, Arnold-Schild, Danielle, Klein, Matthias, Stassen, Michael, Marini, Federico, Pielenhofer, Jonas, Meiser, Sophie Luise, Langguth, Peter, Mack, Matthias, Muth, Sabine, Probst, Hans-Christian, Schild, Hansjörg, Radsak, Markus Philipp   +14 more
openaire   +5 more sources

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

INVESTIGATION OF THE EFFECTS OF JUGLONE AND CISPLATIN ON BREAST CANCER CELL LINES

International Journal of Health Services Research and Policy
Breast cancer is one of the most commonly diagnosed malignancies worldwide, accounting for approximately 11% of all cancer-related deaths. Cisplatin induces DNA damage, thereby leading to apoptotic cell death, while juglone, a phytochemical compound ...
Selda Şimşek, Buket Er Urgancı, Sacide Çakal   +2 more
doaj   +1 more source

Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus

Scientific Reports, 2023
Generalized status epilepticus (SE) triggers a robust neuroinflammatory response involving reactive astrocytosis, activation of brain-resident microglia, and brain infiltration of CCR2+ monocytes.
Carlos Alemán-Ruiz, Wenyi Wang, Ray Dingledine, Nicholas H. Varvel   +3 more
doaj   +1 more source