Results 51 to 60 of about 22,248 (218)

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. [PDF]

, 2017
Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory elements, but the molecular basis, extent, and impact of these alterations are still being unraveled.
Burgos, E, Cavazza, A, Cejas, P, Feliu, J, Goel, A, Horst, D, Mendiola, M, Moreno, V, Moreno-Rubio, J, Shivdasani, RA, Taing, L, Yandava, CN   +11 more
core   +1 more source

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

G3: Genes, Genomes, Genetics, 2018
The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese   +5 more
doaj   +1 more source

Translational control of ERK signaling through miRNA/4EHP-directed silencing

eLife, 2018
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs.
Seyed Mehdi Jafarnejad, Clément Chapat, Edna Matta-Camacho, Idit Anna Gelbart, Geoffrey G Hesketh, Meztli Arguello, Aitor Garzia, Sung-Hoon Kim, Jan Attig, Maayan Shapiro, Masahiro Morita, Arkady Khoutorsky, Tommy Alain, Christos, G Gkogkas, Noam Stern-Ginossar, Thomas Tuschl, Anne-Claude Gingras, Thomas F Duchaine, Nahum Sonenberg   +18 more
doaj   +1 more source

Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]

PLoS ONE, 2012
Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki, Rie Saba, Kei Miyoshi, Yoshinori Morita, Yumiko Saga   +4 more
doaj   +1 more source

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. [PDF]

, 2016
BackgroundGene expression is controlled at multiple levels, including transcription, stability, translation, and degradation. Over the years, it has become apparent that Plasmodium falciparum exerts limited transcriptional control of gene expression ...
Batugedara, Gayani, Bunnik, Evelien M, Florens, Laurence, Le Roch, Karine G, Prudhomme, Jacques, Saraf, Anita   +5 more
core   +2 more sources

Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex [PDF]

Structure, 2015
The Ccr4-Not complex regulates eukaryotic gene expression at multiple levels, including mRNA turnover, translational repression, and transcription. We have studied the ubiquitylation module of the yeast Ccr4-Not complex and addressed how E3 ligase binds cognate E2 and how it is tethered to the complex.
Bhaskar V., Basquin J., Conti E.
openaire   +3 more sources

The Ccr4‐Not complex is a key regulator of eukaryotic gene expression [PDF]

WIREs RNA, 2016
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Villanyi Zoltan, Collart Martine A.
openaire   +7 more sources

Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation

Frontiers in Genetics, 2014
The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj   +1 more source

Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

eLife, 2020
Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a population level remain uncharacterized. We find that two PUF family RNA-binding proteins FBF-1 and FBF-2 have opposite
Xiaobo Wang, Mary Ellenbecker, Benjamin Hickey, Nicholas J Day, Emily Osterli, Mikaya Terzo, Ekaterina Voronina   +6 more
doaj   +1 more source

Post-transcriptional control of tumor cell autonomous metastatic potential by the CCR4-NOT deadenylase CNOT7 [PDF]

, 2016
Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
A Aslam, A Boland, A Charlesworth, A Suzuki, A Yamashita, AM Zubiaga, AP Petit, B Loh, C Chen, CJ Aslakson, CJ Decker, CT Guy, E Wahle, EE Schadt, EJ Chesler, F Faraji, F Faraji, Farhoud Faraji, G. Sebastian Winkler, GS Winkler, H Sandler, Howard H. Yang, I Behm-Ansmant, IJ Fidler, J Van Etten, J Yang, K Ito, K Ito, K Ogami, K Ryan, Kent W. Hunter, KJ Luzzi, L Lukes, L Ma, Laura Corbo, M Fenger-Gron, M Horiuchi, M Maekawa, M Ringner, M Tucker, MA Collart, MA Collart, Markus Hafner, Maxwell P. Lee, MW Helms, N Hosoda, NC Lau, NP Crawford, P Viswanathan, RP Wharton, S Jayne, S Matsuda, S Mittal, S Valastyan, SA Mani, SF Tavazoie, SF Winter, T Lifsted, T Nakamura, TK Albert, W Joly, X Li, X Zheng, XF Pei, Y Funakoshi, Ying Hu   +65 more
core   +4 more sources