Results 61 to 70 of about 22,248 (218)

The CCR4–NOT complex suppresses untimely translational activation of maternal mRNAs

Development, 2023
ABSTRACT Control of mRNA poly(A) tails is essential for regulation of mRNA metabolism, specifically translation efficiency and mRNA stability. Gene expression in maturing oocytes relies largely on post-transcriptional regulation, as genes are transcriptionally silent during oocyte maturation.
Shou Soeda, Masaaki Oyama, Hiroko Kozuka-Hata, Tadashi Yamamoto   +3 more
openaire   +2 more sources

MicroRNA in control of gene expression: An overview of nuclear functions [PDF]

, 2016
The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the
Catalanotto, Caterina, Cogoni, Carlo, Zardo, Giuseppe   +2 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer. [PDF]

PLoS ONE, 2015
Cellular chemotaxis is the best-known function of chemokine receptors which are closely linked with tumor metastasis. In fact, positive expression of chemokine receptors could also be identified even in some patients without metastatic tumors, while the ...
Yongmei Yang, Lutao Du, Xiaoyun Yang, Ailin Qu, Xin Zhang, Chengjun Zhou, Chuanxin Wang   +6 more
doaj   +1 more source

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

, 2019
The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Conti, E., Reichelt, P., Schuller, J., Schäfer, I., Schüssler, S., Strauss, M., Yamashita, M.   +6 more
core   +1 more source

Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication [PDF]

, 2018
Hepatitis C virus (HCV) is a positive sense RNA virus that persistently infects human liver, leading to cirrhosis and hepatocellular carcinoma. HCV replication requires the liver-specific microRNA-122 (miR-122).
Aimee L Parsons, Biegel, Bradrick, Braun, Catherine L Jopling, Chekulaeva, Chen, Choudhary Shoaib Ahmed, Duffy, Fabian, Galicia-Vazquez, Galicia-Vazquez, Henke, Huys, Ikeda, Iwakawa, Iwasaki, Jangra, Jangra, Jopling, Jopling, Kuzuoglu-Ozturk, Kyono, Li, Li, Li, Li, Lindenbach, Luna, Masaki, Mathys, Meijer, Norman, Pawlotsky, Pestova, Poppy L Winlow, Radle, Roberts, Roberts, Ruggieri, Scheel, Scheel, Scheller, Schweingruber, Sedano, Spriggs, Thibault, Thrift, Yi   +48 more
core   +2 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]

, 2010
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P., Brockington, A., Carmeliet, P., Claes, F., Heath, P.R., Holden, H., Kasher, P., Lambrechts, D., Sendtner, M., Shaw, P.J.   +9 more
core   +4 more sources

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

CCR4/NOT complex associates with the proteasome and regulates histone methylation [PDF]

Proceedings of the National Academy of Sciences, 2007
The proteasome regulates histone lysine methylation and gene transcription, but how it does so is poorly understood. To better understand this process, we used the epistatic miniarray profile (E-MAP) approach to identify factors that genetically interact with proteasomal subunits.
R Nicholas, Laribee, Yoichiro, Shibata, Douglas P, Mersman, Sean R, Collins, Patrick, Kemmeren, Assen, Roguev, Jonathan S, Weissman, Scott D, Briggs, Nevan J, Krogan, Brian D, Strahl   +9 more
openaire   +2 more sources