Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants [PDF]
eLife, 2021 Phytochromes are photoreceptors regulating growth and development in plants. Using the model plant Arabidopsis, we identified a novel signalling pathway downstream of the far-red light-sensing phytochrome, phyA, that depends on the highly conserved CCR4 ...
Philipp Schwenk +10 more
doaj +2 more sources
Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex [PDF]
Frontiers in Immunology, 2021 Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama +2 more
doaj +2 more sources
The Regulatory Properties of the Ccr4–Not Complex [PDF]
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
doaj +2 more sources
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex [PDF]
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +2 more sources
Roles of a CCR4–NOT complex component GmNOT4-1 in regulating soybean nodulation [PDF]
Frontiers in Plant Science, 2023 Legume-rhizobial symbiotic nitrogen fixation is the most efficient nitrogen assimilation system in the ecosystem. In the special interaction between organ–root nodules, legumes supply rhizobial carbohydrates for their proliferation, while rhizobials ...
Jiangtao Zheng +7 more
doaj +2 more sources
Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability [PDF]
Cells, 2023 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim +6 more
doaj +2 more sources
The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity. [PDF]
PLoS Genetics, 2020 The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen +3 more
doaj +2 more sources
Structure and assembly of the NOT10:11 module of the CCR4-NOT complex [PDF]
Communications Biology, 2023 NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood.
Yevgen Levdansky +6 more
doaj +2 more sources
Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization [PDF]
Genome Biology, 2021 Background Regulation of protein output at the level of translation allows for a rapid adaptation to dynamic changes to the cell’s requirements. This precise control of gene expression is achieved by complex and interlinked biochemical processes that ...
Sarah L. Gillen +5 more
doaj +2 more sources
Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena [PDF]
Frontiers in Genetics, 2014 The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai +5 more
doaj +2 more sources