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Structure and assembly of the NOT module of the human CCR4–NOT complex
Nature Structural & Molecular Biology, 2013The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland +7 more
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Global control of gene expression in yeast by the Ccr4-Not complex
Gene, 2003The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It is a large complex that in the yeast Saccharmyces cerevisiae exists in two prominent forms of 0.9-1.2 and 1.9-2 MDa, and consists of at least nine core subunits: the five Not proteins (Not1p to Not5p), Caf1p, Caf40p, Caf130p and Ccr4p.
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Carbon source dependent dynamics of the Ccr4-Not complex in Saccharomyces cerevisiae
The Journal of Microbiology, 2008We have investigated the composition of the conserved Ccr4-Not complex during different physiological states of Saccharomyces cerevisiae. Major changes were found, most notably in the expression of the central scaffold protein Not1p, which was strongly reduced in the absence of glucose. The low expression of Not1p was also evident from the inability of
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CA: A Cancer Journal for Clinicians--What's New and What's Not
Ca-A Cancer Journal for Clinicians, 2002exaly
SCREENING MESSAGES NOT REACHING CRITICAL AUDIENCE, STUDY FINDS
Ca-A Cancer Journal for Clinicians, 2008exaly