Results 81 to 90 of about 13,668 (163)

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang, Shan Bu, Yuxin Nie, Luyou Wang, Jiayi Liu, Junchen Xu, Jiejun Peng, Fei Yan, Jian Wu   +8 more
wiley   +1 more source

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis

Plant, Cell &Environment, EarlyView.
ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley, Asa Budnick, Simona Radutoiu, Heike Sederoff   +3 more
wiley   +1 more source

Roles of the yeast Ccr4‐Not complex in regulating transcription

The FASEB Journal, 2010
The highly conserved Ccr4‐Not complex has been ascribed many functions, from transcription regulation to mRNA decay. Initial studies described a role of this complex in preinitiation complex formation, but a number of studies have clearly shown Ccr4‐Not mediates deadenylation of mRNAs and
Arnob Dutta, Jennifer A Kruk, David S Gilmour, Joseph C Reese   +3 more
openaire   +1 more source

Assessing the adaptive potential of European beech populations to temperature and precipitation along a steep environmental gradient in the south‐eastern Carpathians

Plant Biology, EarlyView.
This study focuses on the identification of candidate SNPs involved in local adaptation to altitude by environmental association analysis conducted on different natural European beech (Fagus sylvatica) populations. Abstract It is necessary to assess the adaptive potential of European beech populations to climate change.
M. Tost, O. Grigoriadou‐Zormpa, S. Wilhelmi, M. Müller, H. Wildhagen, A. L. Curtu, O. Gailing   +6 more
wiley   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

Human DDX6 regulates translation and decay of inefficiently translated mRNAs

eLife
Recent findings indicate that the translation elongation rate influences mRNA stability. One of the factors that has been implicated in this link between mRNA decay and translation speed is the yeast DEAD-box helicase Dhh1p.
Ramona Weber, Chung-Te Chang
doaj   +1 more source

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR‐Based Genetic Analyses and Experimental Models

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 2, Page 127-143, March 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.
Zuqing Nie, Xinyi Xu, Junhao Chen, Huiling Chen, Meng Li, Yang Zhang, Zhiwei Li, Chen Shen, Jie Wen, Xia Cao   +9 more
wiley   +1 more source