Results 131 to 140 of about 34,412 (225)

Altered Cytokine‐Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine‐Non‐Responsiveness in Aging and HIV

Aging Cell, Volume 25, Issue 3, March 2026.
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Sheldon Davis, Jonah Kupritz, Prabhsimran Singh, Savita Pahwa, Suresh Pallikkuth   +4 more
wiley   +1 more source

C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA).
Aga Krisnanda, Naoto Sasaki, Toru Tanaka, Ken Ito, Takuo Emoto, Takeshi Yoshida, Hilman Zulkifli Amin, Sayo Horibe, Gusty Rizky Teguh Ryanto, Noriaki Emoto, Tomoya Yamashita, Ken‐ichi Hirata, Kazuhiko Matsuo, Takashi Nakayama, Yoshiyuki Rikitake   +14 more
doaj   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Recent trends of incidence and mortality of cutaneous lymphomas in Germany

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 3, Page 351-358, March 2026.
Summary Background Primary cutaneous lymphomas (PCL) are primarily composed of cutaneous T‐cell lymphomas (CTCL), followed by cutaneous B‐cell lymphomas (CBCL). This study aimed to assess the incidence and survival rates of PCL in Germany. Methods We analyzed data from the North Rhine‐Westphalia Cancer Registry (2008–2021), which covers a population of
Khodr Cheikh El Najjarine, Hiltraud Kajüter, Ina Wellmann, Andreas Stang, Chalid Assaf   +4 more
wiley   +1 more source

Polymorphism in CCR4 Gene (1014 C/T) in Patients with Breast Carcinoma from the South of Iran

Armaghane Danesh Bimonthly Journal, 2013
Background & aim: CCR4 gene polymorphism at position C/T1014 has been associated with changes in mRNA stability and is involved expression of this molecule.
F Moghaddasi, MR Haghshenas, S Naeimi
doaj  

Aktuelle Trends der Inzidenz und Mortalität kutaner Lymphome in Deutschland

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 3, Page 351-359, March 2026.
Zusammenfassung Hintergrund Primäre kutane Lymphome (primary cutaneous lymphomas, PCL) bestehen hauptsächlich aus kutanen T‐Zell‐Lymphomen (cutaneous T‐cell lymphomas, CTCL), gefolgt von kutanen B‐Zell‐Lymphomen (cutaneous B‐cell lymphomas, CBCL). Ziel dieser Studie war es, die Inzidenz und Überlebensraten von PCL in Deutschland zu ermitteln.
Khodr Cheikh El Najjarine, Hiltraud Kajüter, Ina Wellmann, Andreas Stang, Chalid Assaf   +4 more
wiley   +1 more source

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells [PDF]

, 2018
The persistence of HIV reservoirs, including latently infected, resting CD4+ T cells, is the major obstacle to cure HIV infection. CD32a expression was recently reported to mark CD4+ T cells harboring a replication-competent HIV reservoir during ...
Abdel-Mohsen, Mohamed, Betts, Michael R., Buzon, Maria J., Castellvi, Josep, Cox, Kara, Del Rio Estrada, Perla M., Frank, Ian, Genesca, Meritxell, Giron, Leila B., Gonzalez-Navarro, Mauricio, Grau-Exposito, Judith, Hazuda, Daria, Howell, Bonnie, King, Collin T., Kostman, Jay, Kuri-Cervantes, Leticia, Li, Qingsheng, Lynn, Kenneth, Martinez-Picado, Javier, Montaner, Luis J., Mounzer, Karam, Nell, Racheal A., Paiardini, Mirko, Planelles, Vicente, Reyes-Teran, Gustavo, Richman, Douglas, Serra-Peinado, Carla, Spivak, Adam M., Tebas, Pablo, Tomescu, Costin, Vadrevu, Surya Kumari, Vemula, Sai, Wan, Yanmin, Wu, Guoxin   +33 more
core   +1 more source

Comparison Between Phenotypic Profile and Functional Aspects of IL‐9‐Producing Lymphocytes, Th17 and Tfh of Individuals From Endemic and Non‐Endemic Areas for Hookworm Infection

Parasite Immunology, Volume 48, Issue 3, March 2026.
ABSTRACT Hookworm infections remain a major public health concern in endemic areas, modulating both the adaptive and innate immune systems. While the type 2 response is well‐characterised, the roles of T follicular helper (Tfh), Th17, and IL‐9‐producing lymphocytes remain poorly defined.
Yvanna Louise Di Christine Oliveira, Marcelo Eduardo Cardozo, Luisa Mourão Dias Magalhães, Carlos Thailan de Jesus Santos, Ramayana Morais de Medeiros Brito, Luciana Maria de Oliveira, Ana Carolina Amado Gomes, Vinícius Torres Castro Campos, Ricardo Toshio Fujiwara, Silvio Santana Dolabella, Lilian Lacerda Bueno   +10 more
wiley   +1 more source

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

Th2型趋化因子受体CCR4在原位肝移植急性排斥反应中的表达

Zhongguo shiyan zhenduanxue, 2005
目的　通过检测Th2型趋化因子受体CCR4在移植肝脏急性排斥反应中的表达,探讨Th2型细胞在肝移植急性排斥反应中的作用机制。方法　根据Banff病理分级将原位肝移植术后肝穿刺活检标本分成4组,应用RT -PCR方法半定量分析各组标本中CCR4的mRNA水平。结果　轻度排斥组中11例CCR4高水平表达;中度排斥组中6例、未排斥组中5例CCR4中度水平表达;正常对照组、重度排斥组CCR4均轻度表达。结论　肝移植免疫微环境中CCR4的表达可能与免疫耐受的诱导有关;Th1 ...
孟醒初, 张家颖, 朱志军, 宋燕
doaj