Results 41 to 50 of about 34,412 (225)

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction

Frontiers in Endocrinology, 2023
Background/AimsChemokines are known to play critical roles mediating inflammation in many pathophysiological processes. The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity ...
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Joaquin Ortega, Joaquin Ortega, José T. Real, José T. Real, José T. Real, María J Sanz, María J Sanz, María J Sanz, Laura Piqueras, Laura Piqueras, Laura Piqueras   +16 more
doaj   +1 more source

The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]

, 2012
XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain, Newbury, Sarah Faith, Zabolotskaya, Maria Vasilyevna   +2 more
core   +1 more source

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

Human Ccr4–Not complexes contain variable deadenylase subunits [PDF]

Biochemical Journal, 2009
The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity.
Lau, N.C., Kolkman, A., van Schaik, F.M.A., Mulder, K.W., Pijnappel, W.W.M., Heck, A.J.R., Timmers, H.T.M.   +6 more
openaire   +3 more sources

CCR6+ Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis [PDF]

, 2015
Introduction: Patients with rheumatoid arthritis (RA) can be separated into two major subpopulations based on the absence or presence of serum anti-citrullinated protein antibodies (ACPAs).
Davelaar, N. (Nadine), Hamburg, J.P. (Jan Piet) van, Hazes, J.M.W. (Mieke), Jong, P.H.P. (Pascal) de, Lubberts, E.W. (Erik), Paulissen, S.M.J. (Sandra), Vroman, H. (Heleen)   +6 more
core   +1 more source

Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection

Drug Design, Development and Therapy, 2020
Amanda L Blackmon,1 Lauren Pinter-Brown1,2 1Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA; 2Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA ...
Blackmon AL, Pinter-Brown L
doaj  

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports, 2015
The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu, Cuiyun Geng, Hui Wang, Zhihao Yang, Changjiang Weng, Hua Li, Lamei Deng, Luping Liu, Nan Liu, Jianquan Ni, Ting Xie   +10 more
doaj   +1 more source

RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation

Scientific Reports, 2022
Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé, Fabien Velilla, Aymeric Chartier, April Rich, Anne-Ruxandra Carvunis, Claude Sardet, Martine Simonelig, Bijan Sobhian   +7 more
doaj   +1 more source

CCR4+ Skin-Tropic Phenotype as a Feature of Central Memory CD8+ T Cells in Healthy Subjects and Psoriasis Patients

Frontiers in Immunology, 2020
The chemokine receptor CCR4 has emerged as a skin-homing molecule important for the migration of T cells from the blood to the dermis. From our previous data on psoriasis patients, CCR4+ memory T cells emerged as a putative recirculating population ...
Fabio Casciano, Marco Diani, Andrea Altomare, Francesca Granucci, Paola Secchiero, Giuseppe Banfi, Giuseppe Banfi, Eva Reali   +7 more
doaj   +1 more source