Results 81 to 90 of about 34,412 (225)
The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]
International Journal of Molecular Sciences, 2019 Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
Akinori Takahashi +7 more
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez +6 more
wiley +1 more source
Human beta defensin 2 selectively inhibits HIV-1 in highly permissive CCR6+CD4+ T cells [PDF]
, 2017 Chemokine receptor type 6 (CCR6)+CD4+ T cells are preferentially infected and depleted during HIV disease progression, but are preserved in non-progressors.
Aaron Christensen-Quick +7 more
core +1 more source
miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]
, 2020 microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria +6 more
core +1 more source
CCR4-bearing T cells participate in autoimmune diabetes [PDF]
Journal of Clinical Investigation, 2002 Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells. CCR4 was found exclusively on memory CD4(+) T cells during the progression of disease in NOD mice.
Kim, Soon H. +4 more
openaire +3 more sources
Cancer Science, EarlyView.This study found immune markers that may predict how well patients with advanced lung cancer respond to atezolizumab. Higher levels of certain T cells were linked to better survival. Specific patterns suggested a worse prognosis for some patients. ABSTRACT We investigated immunologic biomarkers that predict outcomes of patients with previously treated ...
Atsuto Mouri +24 more
wiley +1 more source
Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach [PDF]
, 2015 Additional file 2: Table S2. The complete list of genes down regulated in Th17 versus Th1 subsets are included and classified based on p-values
Annie Gosselin +14 more
core +6 more sources
Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
core +2 more sources
Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults
Clinical &Experimental Allergy, EarlyView.After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère +7 more
wiley +1 more source
E2F2 stimulates CCR4 expression and activates synovial fibroblast-like cells in rheumatoid arthritis
Central European Journal of Immunology, 2021 Wanju Xu, Shufeng Li, Xiaotian Chang
doaj +1 more source