Results 21 to 30 of about 7,732 (197)

CD155: A Multi-Functional Molecule in Tumor Progression [PDF]

International Journal of Molecular Sciences, 2020
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including ...
Molfetta R., Zitti B., Lecce M., Milito Nadia Domenica, Stabile H., Fionda C., Cippitelli M., Gismondi A., Santoni A., Paolini R.   +9 more
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CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis

Clinical and Translational Medicine, 2022
Background Hepatocellular carcinoma (HCC) is a prevalent malignancy with poor prognosis. As a cell adhesion molecule, poliovirus receptor (PVR/CD155) is abnormally overexpressed in tumour cells, and related to tumour proliferation and invasion.
An‐Li Jin, Chun‐Yan Zhang, Wen‐Jing Zheng, Jing‐Rong Xian, Wen‐Jing Yang, Te Liu, Wei Chen, Tong Li, Bei‐Li Wang, Bai‐Shen Pan, Qian Li, Jian‐Wen Cheng, Peng‐Xiang Wang, Bo Hu, Jian Zhou, Jia Fan, Xin‐Rong Yang, Wei Guo   +17 more
doaj   +1 more source

Clinical significance of CD155 expression and correlation with cellular components of tumor microenvironment in gastric adenocarcinoma

Frontiers in Immunology, 2023
IntroductionCD155 is recently emerging as a promising target in malignancies. However, the relationship between CD155 expression and tumor microenvironment (TME) cell infiltration in gastric adenocarcinoma (GAC) has rarely been clarified.MethodsWe ...
Xue Liu, Xue Liu, Chenyang Xu, Chenyang Xu, Tianwei Guo, Shenghua Zhan, Qiuying Quan, Mengsi Li, Mengsi Li, Ziyi Wang, Ziyi Wang, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Lingchuan Guo, Lei Cao, Lei Cao, Lei Cao   +17 more
doaj   +1 more source

CD155 promotes radioresistance and malignancy of esophageal cancer by regulating Hippo-YAP pathway

Discover Oncology, 2022
The expression of CD155 has been observed to increase in various human cancers, but its role in the development of esophageal cancer (EC) is unclear. Radiotherapy is one of the primary therapeutic options for EC.
Huixian Xin, Yuchen Liu, Pengxiang Chen, Tianwen Yin, Meijie Wang, Tianyu Liu, Zhihua Wen, Yufeng Cheng   +7 more
doaj   +1 more source

Poliovirus receptor CD155-targeted oncolysis of glioma [PDF]

Neuro-Oncology, 2004
Cell adhesion molecules of the immunoglobulin superfamily are aberrantly expressed in malignant glioma. Amongst these, the human poliovirus receptor CD155 provides a molecular target for therapeutic intervention with oncolytic poliovirus recombinants. Poliovirus has been genetically modified through insertion of regulatory sequences derived from human ...
Melinda K, Merrill, Guenter, Bernhardt, John H, Sampson, Carol J, Wikstrand, Darell D, Bigner, Matthias, Gromeier   +5 more
openaire   +2 more sources

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]

, 2016
Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA, Bilotta, MARIA TERESA, Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Petrucci, MARIA TERESA, Ricciardi, Maria Rosaria, Santoni, Angela, Soriani, Alessandra, Vulpis, Elisabetta, Zingoni, Alessandra, Zitti, Beatrice   +13 more
core   +15 more sources

Prognostic value of CD155/TIGIT expression in patients with colorectal cancer.

PLoS ONE, 2022
IntroductionThe interaction of CD155 with its ligand, the T cell immunoreceptor with Ig and ITIM domains (TIGIT), is being studied owing to its potential to act as a target in the treatment of various solid tumors. However, the relationship between CD155
Daisuke Murakami, Kenji Matsuda, Hiromitsu Iwamoto, Yasuyuki Mitani, Yuki Mizumoto, Yuki Nakamura, Ibu Matsuzaki, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata, Hiroki Yamaue   +11 more
doaj   +1 more source

MD Simulation Reveals Regulation of Mechanical Force and Extracellular Domain 2 on Binding of DNAM-1 to CD155

Molecules, 2023
Two extracellular domains of the adhesive receptor DNAM-1 are involved in various cellular biological processes through binding to ligand CD155, usually under a mechano-microenvironment. The first extracellular domain (D1) plays a key role in recognition,
Liping Fang, Yang Zhao, Pei Guo, Ying Fang, Jianhua Wu   +4 more
doaj   +1 more source

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]

PLoS ONE, 2012
BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.
Zaynah Maherally, James R Smith, Qian An, Geoffrey J Pilkington   +3 more
doaj   +1 more source

Targeting PVR (CD155) and its receptors in anti-tumor therapy [PDF]

Cellular & Molecular Immunology, 2018
Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions. In contrast to healthy tissues, PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive ...
Paola Kučan Brlić, Tihana Lenac Roviš, Guy Cinamon, Pini Tsukerman, Ofer Mandelboim, Stipan Jonjić   +5 more
openaire   +7 more sources