Results 91 to 100 of about 37,805 (220)

Regulation of the T Cell Response by CD39 [PDF]

Trends in Immunology, 2016
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine.
Maisa C, Takenaka, Simon, Robson, Francisco J, Quintana   +2 more
openaire   +2 more sources

Interleukin‐2 deprived state of regulatory T cells and their recovery by low‐dose interleukin‐2 in patients with inflammatory myopathies

Arthritis &Rheumatology, Accepted Article.
Objective Regeneration and expansion of regulatory T cells (Treg) by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg‐IL‐2 axis emerge in ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse [PDF]

Cardiovascular Research, 2009
Extracellular nucleotides are vasoactive molecules. The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice.Immunofluorescence, enzyme histochemistry, and HPLC analysis were used to
Kauffenstein, Gilles, Drouin, Annick, Thorin-Trescases, Nathalie, Bachelard, Hélène, Robaye, Bernard, D'Orléans-Juste, Pedro, Marceau, François, Thorin, Eric, Sévigny, Jean   +8 more
openaire   +2 more sources

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signaling [PDF]

, 2015
The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis.
Christy, Marc, Haque-Begum, Sakhina, Kasper, Dennis L., Kasper, Eli J., Kasper, Lloyd H., Ochoa-Repáraz, Javier, Robson, Simon C., Telesford, Kiel M., Wang, Li, Wang, Yan, Wu, Yan   +10 more
core   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

CD39 expression defines exhausted CD4+ T cells associated with poor survival and immune evasion in human gastric cancer

Clinical & Translational Immunology
Objectives CD4+ T cell helper and regulatory function in human cancers has been well characterised. However, the definition of tumor‐infiltrating CD4+ T cell exhaustion and how it contributes to the immune response and disease progression in human ...
Zhen‐quan Duan, Yu‐xian Li, Yuan Qiu, Yang Shen, Ying Wang, Yuan‐yuan Zhang, Bao‐hang Zhu, Xiao‐hong Yu, Xue‐ling Tan, Weisan Chen, Yuan Zhuang, Ping Cheng, Wei‐jun Zhang, Quan‐ming Zou, Dai‐yuan Ma, Liu‐sheng Peng   +15 more
doaj   +1 more source

Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. [PDF]

, 2015
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system.
Anderton, Ando, Andres, Apetoh, Astier, Awasthi, Bacchetta, Bacchetta, Barrat, Batten, Bennett, Borsellino, Brunkow, Cedeno-Laurent, Chen, Chen, Dalla Libera, Darrasse-Jeze, David, Dominguez-Villar, Durelli, El-Behi, Faria, Fitzgerald, Fitzgerald, Fitzgerald, Fletcher, Fontenot, Frisullo, Gagliani, Gandhi, Garin, Getts, Getts, Gregory, Groux, Haak, Haas, Haas, Harrington, Hilliard, Hong, Hori, Huan, Huang, Huber, Hunter, Iellem, Ilarregui, Jiang, Joller, Kipnis, Kohm, Komiyama, Kopcow, Korn, Korn, Korporal, Kroenke, Kuniyasu, Langrish, Laouar, Leech, Leonard, Li, Liblau, Lutterotti, Magnani, Mariathasan, Markiewicz, Martinez-Forero, Mascanfroni, McGeachy, Mehling, Miller, Mosmann, Muls, Noseworthy, O'Connor, Ohnmacht, Peng, Pflanz, Pflanz, Pitkanen, Pot, Pot, Pot, Rabinovich, Ramgolam, Ratts, Read, Rostami, Rovetto, Russell, Sakaguchi, Secor, Segal, Sela, Smith, Stephens, Stumhofer, Sundstedt, Takahashi, Takeda, Tigno-Aranjuez, Toscano, Turley, Tzartos, Uyttenhove, Veen, Venken, Venken, Vieira, Viglietta, Villarino, Voskuhl, Wang, Wang, Weiner, Wildbaum, Wildin, Xu, Yamaguchi, Yamazaki, Yang, Yang, Zhang, Zhang, Zhang, Zhang   +129 more
core   +2 more sources

Palmitoylation Targets CD39/Endothelial ATP Diphosphohydrolase to Caveolae [PDF]

Journal of Biological Chemistry, 2000
Ectonucleotidases influence purinergic receptor function by the hydrolysis of extracellular nucleotides. CD39 is an integral membrane protein that is a prototype member of the nucleoside 5'-triphosphate diphosphohydrolase family. The native CD39 protein has two intracytoplasmic and two transmembrane domains.
K, Koziak, E, Kaczmarek, A, Kittel, J, Sévigny, J K, Blusztajn, J, Schulte Am Esch, M, Imai, O, Guckelberger, C, Goepfert, I, Qawi, S C, Robson   +10 more
openaire   +2 more sources