Results 31 to 40 of about 37,805 (220)
Human Vaccines & Immunotherapeutics, 2018 The field of immunotherapeutics is living an exceptional time as new antibodies that take brakes off T-cells and unleash them on tumours are being approved by the US-Food and Drug Administration (FDA).
Audrey Hubert, Nabila Seddiki
doaj +1 more source
CD39 and CD73 in immunity and inflammation [PDF]
Trends in Molecular Medicine, 2013 The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. This drives a shift from an ATP-driven proinflammatory environment to an anti-inflammatory milieu induced ...
ANTONIOLI, LUCA +3 more
openaire +3 more sources
CD39 – A bright target for cancer immunotherapy
Biomedicine & Pharmacotherapy, 2022 The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumor microenvironment, and cancer immune evasion largely involves the generation of high amounts of immunosuppressive extracellular adenosine (eADO). Consequently, inhibition of eADO-generating enzymes and/or eADO receptors can effectively restore the ...
Shuwei, Guo, Fengfeng, Han, Wei, Zhu
openaire +2 more sources
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
CD39 Is an Ecto-(Ca2+,Mg2+)-apyrase [PDF]
Journal of Biological Chemistry, 1996 CD39, a 70- to 100-kDa molecule expressed primarily on activated lymphoid cells, was previously identified as a surface marker of Epstein Barr virus (EBV)-transformed B cells. In this report, we show that an ecto-(Ca2+,Mg2+)-apyrase activity is present on EBV-transformed B cells, but not on B or T lymphomas.
T F, Wang, G, Guidotti
openaire +2 more sources
Biomedicines, 2021 Asthma is a chronic respiratory inflammatory disease. Patients usually suffer long-term symptoms and high medical expenses. Extracellular ATP (eATP) has been identified as a danger signal in innate immunity and serves as a potent inflammatory mediator ...
Yung-An Huang +6 more
doaj +1 more source
The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice [PDF]
, 2013 Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent diabetes.
Chen, Jiang-Fan +11 more
core +1 more source
Implications of CD39 in immune-related diseases
International Immunopharmacology, 2020 Extracellular adenosine triphosphate (eATP) mediates pro-inflammatory responses by recruiting and activating inflammatory cells. CD39 can hydrolyze eATP into adenosine monophosphate (AMP), while CD73 can convert AMP into the immunosuppressive nucleoside adenosine (ADO).
Jianrui, Zeng +3 more
openaire +2 more sources
Frontiers in Oncology, 2020 The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced ...
Alina V. Meyer +7 more
doaj +1 more source
Circulating gluten-specific FOXP3 + CD39 + regulatory T cells have impaired suppressive function in patients with celiac disease [PDF]
, 2017 Background Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in patients with celiac disease has been well characterized, the role of regulatory T (Treg ...
Anderson, Robert P. +14 more
core +1 more source