Results 41 to 50 of about 37,805 (220)
Frontiers in Genetics, 2021 BackgroundCD39 is one of the functional surface markers for T regulatory cells, the prognostic role and immune-related effects of CD39 in luminal breast cancer (BC) patients has not been evaluated yet.
Xiaojian Ni +13 more
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Science-Business eXchange, 2009 American and German researchers have reported that enhancing CD39 activity in the gut could help treat inflammatory bowel disease. The researchers are now developing a soluble form of CD39 that they hope could become an infusible therapeutic to treat colitis and Crohn's disease.
openaire +1 more source
CD39 Modulates Endothelial Cell Activation and Apoptosis [PDF]
Molecular Medicine, 2000 CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored.Recombinant replication-deficient adenoviruses were constructed ...
C, Goepfert +5 more
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Frontiers in Immunology, 2022 The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory ...
Shi Qian +21 more
doaj +1 more source
Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
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Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity
Journal for ImmunoTherapy of Cancer, 2019 Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to adenosine ...
Abhishek S. Kashyap +10 more
doaj +1 more source
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment
Medicine in Drug Discovery, 2021 ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response.
Zheng Wei +5 more
doaj +1 more source
High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors [PDF]
, 2015 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Aliagas Marín, Elisabeth +5 more
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Immunosuppression-independent role of regulatory T cells against hypertension-driven renal dysfunctions [PDF]
, 2016 Hypertension-associated cardiorenal diseases represent one of the heaviest burdens for current health systems. In addition to hemodynamic damage, recent results have revealed that hematopoietic cells contribute to the development of these diseases by ...
Alarcón, Balbino +11 more
core +1 more source