Results 51 to 60 of about 37,805 (220)
The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance [PDF]
, 2011 Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized.
Robson, Simon Christopher +2 more
core +1 more source
What Else Can CD39 Tell Us? [PDF]
Frontiers in Immunology, 2017 As the rate-limiting enzyme in ATP/ADP-AMP-adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect. In addition, CD39hi Tregs, but not CD25hi Tregs, exhibit sustained Foxp3 levels and functional abilities, indicating it could represent a new specific marker of Tregs.
Zhao, Hai, Bo, Cong, Kang, Yan, Li, Hong
openaire +3 more sources
Immunology, 2022 AbstractThe role of CD39 pathway in Th1 cell function in tuberculosis (TB) is rarely elucidated. The present study aims to investigate the modulating mechanism of CD39 pathway during Mycobacterium tuberculosis (MTB) infection. CD39 expression was examined on host immune cells among patients with TB. The relationship between CD39 expression and Th1 cell
Ying Luo +8 more
openaire +2 more sources
Journal of Animal Reproduction and Biotechnology, 2018 Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No +10 more
doaj +1 more source
Metabolic, mental and immunological effects of normoxic and hypoxic training in multiple sclerosis patients: a pilot study [PDF]
, 2018 Background: Physical activity might attenuate inflammation and neurodegeneration in multiple sclerosis (MS). Erythropoietin, which is produced upon exposure to hypoxia, is thought to act as a neuroprotective agent in MS. Therefore, we studied the effects
Balogh, Andras +9 more
core +3 more sources
陆军军医大学学报Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj +1 more source
Frontiers in Immunology, 2022 Backgroundγδ T cells are unconventional T cells that have been demonstrated to be crucial for the pathogenesis and potentially for the cure of HIV-1 infection. The ectonucleotidase CD39 is part of the purinergic pathway that regulates immune responses by
Katharina Kolbe +15 more
doaj +1 more source
Genetic determinants of co-accessible chromatin regions in activated T cells across humans. [PDF]
, 2018 Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease.
A Barrie +99 more
core +2 more sources
CD39-adenosinergic axis in renal pathophysiology and therapeutics [PDF]
Purinergic Signalling, 2018 Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5'-nucleotidase.
Bellamkonda K. Kishore +2 more
openaire +2 more sources
In vitro Study of a Novel Stent Coating Using Modified CD39 Messenger RNA to Potentially Reduce Stent Angioplasty-Associated Complications. [PDF]
PLoS ONE, 2015 Stent angioplasty provides a minimally invasive treatment for atherosclerotic vessels. However, no treatment option for atherosclerosis-associated endothelial dysfunction, which is accompanied by a loss of CD39, is available, and hence, adverse effects ...
Meike-Kristin Abraham +10 more
doaj +1 more source